2. Anti-infection
  3. Bacterial
  4. TH-Z145

TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 210 nM).

For research use only. We do not sell to patients.

TH-Z145 Chemical Structure

TH-Z145 Chemical Structure

CAS No. : 2260887-57-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 143 In-stock
Solution
10 mM * 1 mL in DMSO USD 143 In-stock
Solid
5 mg USD 130 In-stock
10 mg USD 210 In-stock
25 mg USD 430 In-stock
50 mg USD 690 In-stock
100 mg USD 1100 In-stock
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Based on 1 publication(s) in Google Scholar

TH-Z145 Related Antibodies

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Description

TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 210 nM)[1].

IC50 & Target

FPPS[1]
In Vivo

TH-Z145 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16-OVA cells (s.c.) xenograft mice model[1].
Dosage: 20 μg
Administration: Intraperitoneal injection (i.p.)
Result: Inhibited tumor growth and prolonged survival.
Molecular Weight

394.34

Formula

C16H28O7P2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=P(O)(C(P(O)(O)=O)CC1=CC(OCCCCCCCC)=CC=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (253.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5359 mL 12.6794 mL 25.3588 mL
5 mM 0.5072 mL 2.5359 mL 5.0718 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5359 mL 12.6794 mL 25.3588 mL 63.3971 mL
5 mM 0.5072 mL 2.5359 mL 5.0718 mL 12.6794 mL
10 mM 0.2536 mL 1.2679 mL 2.5359 mL 6.3397 mL
15 mM 0.1691 mL 0.8453 mL 1.6906 mL 4.2265 mL
20 mM 0.1268 mL 0.6340 mL 1.2679 mL 3.1699 mL
25 mM 0.1014 mL 0.5072 mL 1.0144 mL 2.5359 mL
30 mM 0.0845 mL 0.4226 mL 0.8453 mL 2.1132 mL
40 mM 0.0634 mL 0.3170 mL 0.6340 mL 1.5849 mL
50 mM 0.0507 mL 0.2536 mL 0.5072 mL 1.2679 mL
60 mM 0.0423 mL 0.2113 mL 0.4226 mL 1.0566 mL
80 mM 0.0317 mL 0.1585 mL 0.3170 mL 0.7925 mL
100 mM 0.0254 mL 0.1268 mL 0.2536 mL 0.6340 mL
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TH-Z145 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TH-Z1452260887-57-6BacterialBisphosphonateB16-OVAinfluenzaInhibitorinhibitorinhibit

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