2. PROTAC Autophagy Apoptosis
  3. E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis
  4. Thalidomide-4-O-C2-NH2 hydrochloride

Thalidomide-4-O-C2-NH2 hydrochloride 

Cat. No.: HY-136162 Purity: 99.37%
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Thalidomide-4-O-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-4-O-C2-NH2 hydrochloride Chemical Structure

Thalidomide-4-O-C2-NH2 hydrochloride Chemical Structure

CAS No. : 2341840-99-9

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5 mg USD 64 In-stock
10 mg USD 100 In-stock
25 mg USD 200 In-stock
50 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide-4-O-C2-NH2 hydrochloride:

Thalidomide-4-O-C2-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Thalidomide-4-O-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-4-O-C2-NH2 hydrochloride Related Antibodies
Molecular Weight

353.76

Formula

C15H16ClN3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCN)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (353.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8268 mL 14.1339 mL 28.2678 mL
5 mM 0.5654 mL 2.8268 mL 5.6536 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8268 mL 14.1339 mL 28.2678 mL 70.6694 mL
5 mM 0.5654 mL 2.8268 mL 5.6536 mL 14.1339 mL
10 mM 0.2827 mL 1.4134 mL 2.8268 mL 7.0669 mL
15 mM 0.1885 mL 0.9423 mL 1.8845 mL 4.7113 mL
20 mM 0.1413 mL 0.7067 mL 1.4134 mL 3.5335 mL
25 mM 0.1131 mL 0.5654 mL 1.1307 mL 2.8268 mL
30 mM 0.0942 mL 0.4711 mL 0.9423 mL 2.3556 mL
40 mM 0.0707 mL 0.3533 mL 0.7067 mL 1.7667 mL
50 mM 0.0565 mL 0.2827 mL 0.5654 mL 1.4134 mL
60 mM 0.0471 mL 0.2356 mL 0.4711 mL 1.1778 mL
80 mM 0.0353 mL 0.1767 mL 0.3533 mL 0.8834 mL
100 mM 0.0283 mL 0.1413 mL 0.2827 mL 0.7067 mL
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Thalidomide-4-O-C2-NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-4-O-C2-NH22341840-99-9E3 Ligase Ligand-Linker ConjugatesAutophagyApoptosisInhibitorinhibitorinhibit

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