2. PROTAC
  3. Ligands for E3 Ligase
  4. Thalidomide-5-O-C6-NH2 hydrochloride

Thalidomide-5-O-C6-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C6-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.

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Thalidomide-5-O-C6-NH2 hydrochloride Chemical Structure

Thalidomide-5-O-C6-NH2 hydrochloride Chemical Structure

CAS No. : 2761398-05-2

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Thalidomide-5-O-C6-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

Thalidomide-5-O-C6-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C6-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].

Molecular Weight

409.86

Formula

C19H24ClN3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(C=CC(OCCCCCCN)=C2)=C2C(N1C(CC3)C(NC3=O)=O)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation
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Thalidomide-5-O-C6-NH2 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-5-O-C6-NH22761398-05-2Ligands for E3 LigaseE3 ligase-recruiting MoietyMolecular gelcereblon ligandPROTACCRBN proteintarget protein ligandconjugateInhibitorinhibitorinhibit

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