2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-5-PEG4-NH2 hydrochloride

Thalidomide-5-PEG4-NH2 hydrochloride 

Cat. No.: HY-138785A Purity: 95.21%
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Thalidomide-5-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-5-PEG4-NH2 hydrochloride Chemical Structure

Thalidomide-5-PEG4-NH2 hydrochloride Chemical Structure

CAS No. : 2743434-24-2

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5 mg USD 80 In-stock
10 mg USD 130 In-stock
25 mg USD 260 In-stock
50 mg USD 400 In-stock
100 mg USD 600 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide-5-PEG4-NH2 hydrochloride:

Thalidomide-5-PEG4-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Thalidomide-5-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-5-PEG4-NH2 hydrochloride Related Antibodies
Molecular Weight

485.92

Formula

C21H28ClN3O8
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

NCCOCCOCCOCCOC1=CC(C(N2C(C3=O)CCC(N3)=O)=O)=C(C=C1)C2=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (205.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0580 mL 10.2898 mL 20.5795 mL
5 mM 0.4116 mL 2.0580 mL 4.1159 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0580 mL 10.2898 mL 20.5795 mL 51.4488 mL
5 mM 0.4116 mL 2.0580 mL 4.1159 mL 10.2898 mL
10 mM 0.2058 mL 1.0290 mL 2.0580 mL 5.1449 mL
15 mM 0.1372 mL 0.6860 mL 1.3720 mL 3.4299 mL
20 mM 0.1029 mL 0.5145 mL 1.0290 mL 2.5724 mL
25 mM 0.0823 mL 0.4116 mL 0.8232 mL 2.0580 mL
30 mM 0.0686 mL 0.3430 mL 0.6860 mL 1.7150 mL
40 mM 0.0514 mL 0.2572 mL 0.5145 mL 1.2862 mL
50 mM 0.0412 mL 0.2058 mL 0.4116 mL 1.0290 mL
60 mM 0.0343 mL 0.1715 mL 0.3430 mL 0.8575 mL
80 mM 0.0257 mL 0.1286 mL 0.2572 mL 0.6431 mL
100 mM 0.0206 mL 0.1029 mL 0.2058 mL 0.5145 mL
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Thalidomide-5-PEG4-NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-5-PEG4-NH22743434-24-2E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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