2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride

Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride Chemical Structure

Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride Chemical Structure

CAS No. : 2983037-00-7

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Other Forms of Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride:

Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride Related Antibodies
Molecular Weight

586.03

Formula

C25H36ClN5O9
CAS No.
SMILES

O=C(C(CC1)N2C(C3=CC=CC(NCC(NCCOCCOCCOCCOCCN)=O)=C3C2=O)=O)NC1=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-NH-amido-PEG4-C2-NH22983037-00-7E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride
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