Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride

Name: Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride
Brand: MedChemExpress
SKU: HY-138857A
Rating: 4.5 (1 reviews)

Cat. No.: HY-138857A Purity: 98.01%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride Chemical Structure

CAS No. : 2983037-00-7

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride:

Thalidomide-NH-amido-PEG4-C2-NH2 Get quote

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•Related Small Molecules:

•Related Proteins:

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
Purity & Documentation
References
Customer Review

Description

Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology^[1].

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

586.03

Formula

C₂₅H₃₆ClN₅O₉

CAS No.

2983037-00-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(CC1)N2C(C3=CC=CC(NCC(NCCOCCOCCOCCOCCN)=O)=C3C2=O)=O)NC1=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (170.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7064 mL	8.5320 mL	17.0640 mL
5 mM	0.3413 mL	1.7064 mL	3.4128 mL
10 mM	0.1706 mL	0.8532 mL	1.7064 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.01%

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Data Sheet (268 KB) SDS (252 KB)

COA (244 KB) HNMR (298 KB) LCMS (102 KB)

Handling Instructions (2659 KB)

References

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7064 mL	8.5320 mL	17.0640 mL	42.6599 mL
	5 mM	0.3413 mL	1.7064 mL	3.4128 mL	8.5320 mL
	10 mM	0.1706 mL	0.8532 mL	1.7064 mL	4.2660 mL
	15 mM	0.1138 mL	0.5688 mL	1.1376 mL	2.8440 mL
	20 mM	0.0853 mL	0.4266 mL	0.8532 mL	2.1330 mL
	25 mM	0.0683 mL	0.3413 mL	0.6826 mL	1.7064 mL
	30 mM	0.0569 mL	0.2844 mL	0.5688 mL	1.4220 mL
	40 mM	0.0427 mL	0.2133 mL	0.4266 mL	1.0665 mL
	50 mM	0.0341 mL	0.1706 mL	0.3413 mL	0.8532 mL
	60 mM	0.0284 mL	0.1422 mL	0.2844 mL	0.7110 mL
	80 mM	0.0213 mL	0.1066 mL	0.2133 mL	0.5332 mL
	100 mM	0.0171 mL	0.0853 mL	0.1706 mL	0.4266 mL