2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc

Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc can be used for the synthesis of PROTAC BET degrader. (From patent WO2017180417A1 compound s7).

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Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc Chemical Structure

Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc Chemical Structure

CAS No. : 1799711-31-1

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Based on 1 publication(s) in Google Scholar

Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc Related Antibodies

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View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc can be used for the synthesis of PROTAC BET degrader[1]. (From patent WO2017180417A1 compound s7).

IC50 & Target[1]

Cereblon

 

Molecular Weight

634.67

Formula

C30H42N4O11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCCOCCOCCOCCCNC(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)=O)OC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (157.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5756 mL 7.8781 mL 15.7562 mL
5 mM 0.3151 mL 1.5756 mL 3.1512 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5756 mL 7.8781 mL 15.7562 mL 39.3906 mL
5 mM 0.3151 mL 1.5756 mL 3.1512 mL 7.8781 mL
10 mM 0.1576 mL 0.7878 mL 1.5756 mL 3.9391 mL
15 mM 0.1050 mL 0.5252 mL 1.0504 mL 2.6260 mL
20 mM 0.0788 mL 0.3939 mL 0.7878 mL 1.9695 mL
25 mM 0.0630 mL 0.3151 mL 0.6302 mL 1.5756 mL
30 mM 0.0525 mL 0.2626 mL 0.5252 mL 1.3130 mL
40 mM 0.0394 mL 0.1970 mL 0.3939 mL 0.9848 mL
50 mM 0.0315 mL 0.1576 mL 0.3151 mL 0.7878 mL
60 mM 0.0263 mL 0.1313 mL 0.2626 mL 0.6565 mL
80 mM 0.0197 mL 0.0985 mL 0.1970 mL 0.4924 mL
100 mM 0.0158 mL 0.0788 mL 0.1576 mL 0.3939 mL
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Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc1799711-31-1E3 Ligase Ligand-Linker ConjugatesligandlinkerBETdegraderPROTACInhibitorinhibitorinhibit

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