2. PROTAC Autophagy Apoptosis
  3. E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis
  4. Thalidomide-O-C7-acid

Thalidomide-O-C7-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-O-C7-acid Chemical Structure

Thalidomide-O-C7-acid Chemical Structure

CAS No. : 2169266-70-8

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5 mg USD 63 In-stock
10 mg USD 100 In-stock
25 mg USD 200 In-stock
50 mg USD 330 In-stock
100 mg USD 540 In-stock
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Based on 1 publication(s) in Google Scholar

Thalidomide-O-C7-acid Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

  • Biological Activity

  • Purity & Documentation

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Description

Thalidomide-O-C7-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-O-C7-acid Related Antibodies
Molecular Weight

416.42

Formula

C21H24N2O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCCCCCCOC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (240.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4014 mL 12.0071 mL 24.0142 mL
5 mM 0.4803 mL 2.4014 mL 4.8028 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4014 mL 12.0071 mL 24.0142 mL 60.0355 mL
5 mM 0.4803 mL 2.4014 mL 4.8028 mL 12.0071 mL
10 mM 0.2401 mL 1.2007 mL 2.4014 mL 6.0036 mL
15 mM 0.1601 mL 0.8005 mL 1.6009 mL 4.0024 mL
20 mM 0.1201 mL 0.6004 mL 1.2007 mL 3.0018 mL
25 mM 0.0961 mL 0.4803 mL 0.9606 mL 2.4014 mL
30 mM 0.0800 mL 0.4002 mL 0.8005 mL 2.0012 mL
40 mM 0.0600 mL 0.3002 mL 0.6004 mL 1.5009 mL
50 mM 0.0480 mL 0.2401 mL 0.4803 mL 1.2007 mL
60 mM 0.0400 mL 0.2001 mL 0.4002 mL 1.0006 mL
80 mM 0.0300 mL 0.1501 mL 0.3002 mL 0.7504 mL
100 mM 0.0240 mL 0.1201 mL 0.2401 mL 0.6004 mL
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Thalidomide-O-C7-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-O-C7-acid2169266-70-8E3 Ligase Ligand-Linker ConjugatesAutophagyApoptosisInhibitorinhibitorinhibit

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