2. PROTAC
  3. Ligands for E3 Ligase
  4. Thalidomide-pinacolborane

Thalidomide-pinacolborane is a Thalidomide analogue featuring a boronic pinacol ester, otherwise known as a Bpin group, and they are most frequently used in Suzuki reactions. This molecule is an activator for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.

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Thalidomide-pinacolborane Chemical Structure

Thalidomide-pinacolborane Chemical Structure

CAS No. : 2229725-98-6

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Thalidomide-pinacolborane Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

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Description

Thalidomide-pinacolborane is a Thalidomide analogue featuring a boronic pinacol ester, otherwise known as a Bpin group, and they are most frequently used in Suzuki reactions. This molecule is an activator for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.

Molecular Weight

384.19

Formula

C19H21BN2O6
CAS No.
SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(B4OC(C)(C)C(C)(C)O4)=C3)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Thalidomide-pinacolborane Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-pinacolborane2229725-98-6Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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