Thiol-PEG4-alcohol (Synonyms: HS-PEG4-OH)

Cat. No.: HY-133292 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Thiol-PEG4-alcohol Chemical Structure

CAS No. : 90952-27-5

Size	Price	Stock	Quantity
25 mg	USD 33	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 52	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 84	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 146	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Biological Activity
Purity & Documentation
References
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Description

Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

210.29

Formula

C₈H₁₈O₄S

CAS No.

90952-27-5

Appearance

Liquid (Density: 1.098 g/cm³)

Color

Colorless to light yellow

SMILES

SCCOCCOCCOCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (475.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7553 mL	23.7767 mL	47.5534 mL
5 mM	0.9511 mL	4.7553 mL	9.5107 mL
10 mM	0.4755 mL	2.3777 mL	4.7553 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (265 KB) SDS (641 KB)

COA (240 KB) HNMR (133 KB) MS (78 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7553 mL	23.7767 mL	47.5534 mL	118.8835 mL
	5 mM	0.9511 mL	4.7553 mL	9.5107 mL	23.7767 mL
	10 mM	0.4755 mL	2.3777 mL	4.7553 mL	11.8883 mL
	15 mM	0.3170 mL	1.5851 mL	3.1702 mL	7.9256 mL
	20 mM	0.2378 mL	1.1888 mL	2.3777 mL	5.9442 mL
	25 mM	0.1902 mL	0.9511 mL	1.9021 mL	4.7553 mL
	30 mM	0.1585 mL	0.7926 mL	1.5851 mL	3.9628 mL
	40 mM	0.1189 mL	0.5944 mL	1.1888 mL	2.9721 mL
	50 mM	0.0951 mL	0.4755 mL	0.9511 mL	2.3777 mL
	60 mM	0.0793 mL	0.3963 mL	0.7926 mL	1.9814 mL
	80 mM	0.0594 mL	0.2972 mL	0.5944 mL	1.4860 mL
	100 mM	0.0476 mL	0.2378 mL	0.4755 mL	1.1888 mL

Thiol-PEG4-alcohol Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiol-PEG4-alcohol90952-27-5HS-PEG4-OHPROTAC LinkersInhibitorinhibitorinhibit

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