Thioridazine-d₃ hydrochloride

Name: Thioridazine-d 3 hydrochloride
Brand: MedChemExpress
SKU: HY-B0965AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0965AS Purity: 99.19%: FAQs
Data Sheet SDS COA Handling Instructions

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Thioridazine-d₃ (hydrochloride) is the deuterium labeled Thioridazine. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].

For research use only. We do not sell to patients.

Thioridazine-d<sub>3</sub> hydrochloride Chemical Structure

Thioridazine-d₃ hydrochloride Chemical Structure

CAS No. : 1189928-36-6

Size	Price	Stock	Quantity
1 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 585	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Thioridazine-d₃ hydrochloride:

Thioridazine Get quote

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•Related Small Molecules:

•Related Proteins:

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

410.05

Formula

C₂₁H₂₄D₃ClN₂S₂

CAS No.

1189928-36-6

Unlabeled CAS

50-52-2

Appearance

Solid

Color

Brown to dark brown

SMILES

[2H]C([2H])([2H])N(CCCC1)C1CCN2C3=CC(SC)=CC=C3SC4=CC=CC=C42.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 99.19%

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Data Sheet (271 KB) SDS (393 KB)

COA (251 KB) HNMR (97 KB) RP-HPLC (356 KB) LCMS (86 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Tschanz JT, et, al. Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypy. Pharmacol Biochem Behav. 1988 Nov;31(3):519-22. [Content Brief]

[3]. Mu J, et, al. Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer. Oncol Rep. 2014 May;31(5):2107-14. [Content Brief]

[4]. Kang S, et, al. Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012 Sep;17(9):989-97. [Content Brief]

[5]. Loehr AR, et, al. Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors. Cancers (Basel). 2021 Apr 23;13(9):2045. [Content Brief]