Thrombin inhibitor 11

Cat. No.: HY-162109 Purity: 99.77%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Thrombin inhibitor 11 is a thrombin inhibitor, with human and rat K_i values of 65 nM and 10.3 nM, respectively.

For research use only. We do not sell to patients.

Thrombin inhibitor 11 Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1550	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Thrombin inhibitor 11 is a thrombin inhibitor, with human and rat K_i values of 65 nM and 10.3 nM, respectively^[1].

Molecular Weight

579.13

Formula

C₃₂H₃₉ClN₄O₄

Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C(C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](C4)CCC3)=O)=O)CC/C=C/CCCCNC4=O)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (172.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7267 mL	8.6336 mL	17.2673 mL
5 mM	0.3453 mL	1.7267 mL	3.4535 mL
10 mM	0.1727 mL	0.8634 mL	1.7267 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.77%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (257 KB) RP-HPLC (111 KB) MS (219 KB)

Handling Instructions (2659 KB)

References

[1]. Merz ML, et al. De novo development of small cyclic peptides that are orally bioavailable. Nat Chem Biol. 2023 Dec 28. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7267 mL	8.6336 mL	17.2673 mL	43.1682 mL
	5 mM	0.3453 mL	1.7267 mL	3.4535 mL	8.6336 mL
	10 mM	0.1727 mL	0.8634 mL	1.7267 mL	4.3168 mL
	15 mM	0.1151 mL	0.5756 mL	1.1512 mL	2.8779 mL
	20 mM	0.0863 mL	0.4317 mL	0.8634 mL	2.1584 mL
	25 mM	0.0691 mL	0.3453 mL	0.6907 mL	1.7267 mL
	30 mM	0.0576 mL	0.2878 mL	0.5756 mL	1.4389 mL
	40 mM	0.0432 mL	0.2158 mL	0.4317 mL	1.0792 mL
	50 mM	0.0345 mL	0.1727 mL	0.3453 mL	0.8634 mL
	60 mM	0.0288 mL	0.1439 mL	0.2878 mL	0.7195 mL
	80 mM	0.0216 mL	0.1079 mL	0.2158 mL	0.5396 mL
	100 mM	0.0173 mL	0.0863 mL	0.1727 mL	0.4317 mL