1. Membrane Transporter/Ion Channel Neuronal Signaling Others
  2. GABA Receptor Isotope-Labeled Compounds
  3. Tiagabine-d4 hydrochloride

Tiagabine-d4 hydrochloride  (Synonyms: NO050328-dd4 hydrochloride; NO328-d4 hydrochloride; TGB-d4 hydrochloride)

Cat. No.: HY-B0696AS
Handling Instructions

Tiagabine-d4 hydrochloride is deuterated labeled Tiagabine hydrochloride (HY-B0696A). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively.

For research use only. We do not sell to patients.

Tiagabine-d<sub>4</sub> hydrochloride Chemical Structure

Tiagabine-d4 hydrochloride Chemical Structure

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Description

Tiagabine-d4 hydrochloride is deuterated labeled Tiagabine hydrochloride (HY-B0696A). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

416.03

Formula

C20H22D4ClNO2S2

Unlabeled CAS

145821-59-6

SMILES

O=C(C1C([2H])N(CC/C=C(C2=C(C)C=CS2)/C3=C(C)C=CS3)C([2H])C([2H])C1[2H])O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tiagabine-d4 hydrochloride
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HY-B0696AS
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