Tiazofurin (Synonyms: NSC 286193; Riboxamide)

Cat. No.: HY-114570 Purity: 99.84%: FAQs
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Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin also has anti-orthopoxvirus and anti-variola activities.

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Tiazofurin Chemical Structure

CAS No. : 60084-10-8

Size	Price	Stock	Quantity
1 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 675	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1580	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2150	Get quote	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH)^[1]. Tiazofurin also has anti-orthopoxvirus and anti-variola activities^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	3.82 μM Compound: 1	Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 31557614]
HeLa	IC₅₀	3.82 μM Compound: 1; Tiazofurin	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 26859071]
HeLa	IC₅₀	3.82 μM Compound: 1, Tiazofurin	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 23010263]
HeLa	IC₅₀	4.76 μM Compound: 1, NSC-286193, Tiazofurin	Cytotoxicity against HeLa cells after 24 hrs by MTT assay Cytotoxicity against HeLa cells after 24 hrs by MTT assay	[PMID: 16908146]
HL-60	IC₅₀	0.19 μM Compound: 1	Antiproliferative activity against human HL60 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HL60 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 31557614]
HL-60	IC₅₀	0.19 μM Compound: 1; Tiazofurin	Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay	[PMID: 26859071]
HL-60	IC₅₀	0.19 μM Compound: 1, Tiazofurin	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 23010263]
HL-60	IC₅₀	1.84 μM Compound: 1, tiazofurin	Cytotoxicity against human HL60 cell line after 48 hrs by MTT assay Cytotoxicity against human HL60 cell line after 48 hrs by MTT assay	[PMID: 17543526]
HT-29	IC₅₀	0.26 μM Compound: 1	Antiproliferative activity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 31557614]
HT-29	IC₅₀	0.26 μM Compound: 1; Tiazofurin	Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 26859071]
HT-29	IC₅₀	0.89 μM Compound: 1, tiazofurin	Cytotoxicity against human HT29 cell line after 48 hrs by MTT assay Cytotoxicity against human HT29 cell line after 48 hrs by MTT assay	[PMID: 17543526]
HT-29	IC₅₀	1.01 μM Compound: 1, NSC-286193, Tiazofurin	Cytotoxicity against HT29 cells after 24 hrs by MTT assay Cytotoxicity against HT29 cells after 24 hrs by MTT assay	[PMID: 16908146]
Jurkat	IC₅₀	0.04 μM Compound: 1	Antiproliferative activity against human Jurkat cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human Jurkat cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 31557614]
Jurkat	IC₅₀	0.04 μM Compound: 1; Tiazofurin	Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay	[PMID: 26859071]
Jurkat	IC₅₀	0.04 μM Compound: 1, Tiazofurin	Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay	[PMID: 23010263]
Jurkat	IC₅₀	0.14 μM Compound: 1, NSC-286193, Tiazofurin	Cytotoxicity against Jurkat cells after 24 hrs by MTT assay Cytotoxicity against Jurkat cells after 24 hrs by MTT assay	[PMID: 16908146]
Jurkat	IC₅₀	0.51 μM Compound: 1, tiazofurin	Cytotoxicity against human Jurkat T cells after 48 hrs by MTT assay Cytotoxicity against human Jurkat T cells after 48 hrs by MTT assay	[PMID: 17543526]
K562	IC₅₀	1.89 μM Compound: 1	Antiproliferative activity against human K562 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 31557614]
K562	IC₅₀	1.89 μM Compound: 1; Tiazofurin	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 26859071]
K562	IC₅₀	2.09 μM Compound: 1, Tiazofurin	Cytotoxicity against human K562 cells after 72 hrs by MTT assay Cytotoxicity against human K562 cells after 72 hrs by MTT assay	[PMID: 23010263]
K562	IC₅₀	2.98 μM Compound: 1, tiazofurin	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 17543526]
K562	IC₅₀	5.29 μM Compound: 1, NSC-286193, Tiazofurin	Cytotoxicity against human K562 cells after 24 hrs by MTT assay Cytotoxicity against human K562 cells after 24 hrs by MTT assay	[PMID: 16908146]
MCF7	IC₅₀	1.78 μM Compound: 1; Tiazofurin	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 26859071]
MCF7	IC₅₀	6.39 μM Compound: 1, tiazofurin	Cytotoxicity against human MCF7 cell line after 48 hrs by MTT assay Cytotoxicity against human MCF7 cell line after 48 hrs by MTT assay	[PMID: 17543526]
MRC5	IC₅₀	0.36 μM Compound: 1	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31557614]
MRC5	IC₅₀	0.36 μM Compound: 1; Tiazofurin	Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay	[PMID: 26859071]
MRC5	IC₅₀	0.36 μM Compound: 1, Tiazofurin	Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay	[PMID: 23010263]
MRC5	IC₅₀	0.49 μM Compound: 1, tiazofurin	Cytotoxicity against human MRC5 cell line after 48 hrs by MTT assay Cytotoxicity against human MRC5 cell line after 48 hrs by MTT assay	[PMID: 17543526]
MRC5	IC₅₀	0.85 μM Compound: 1, NSC-286193, Tiazofurin	Cytotoxicity against MRC5 cells after 24 hrs by MTT assay Cytotoxicity against MRC5 cells after 24 hrs by MTT assay	[PMID: 16908146]
Raji	IC₅₀	16.06 μM Compound: 1, tiazofurin	Cytotoxicity against human Raji cells after 48 hrs by MTT assay Cytotoxicity against human Raji cells after 48 hrs by MTT assay	[PMID: 17543526]
Raji	IC₅₀	5.28 μM Compound: 1	Antiproliferative activity against human Raji cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human Raji cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 31557614]
Raji	IC₅₀	5.28 μM Compound: 1; Tiazofurin	Antiproliferative activity against human Raji cells after 72 hrs by MTT assay Antiproliferative activity against human Raji cells after 72 hrs by MTT assay	[PMID: 26859071]
Raji	IC₅₀	5.28 μM Compound: 1, Tiazofurin	Cytotoxicity against human Raji cells after 72 hrs by MTT assay Cytotoxicity against human Raji cells after 72 hrs by MTT assay	[PMID: 23010263]

Molecular Weight

260.27

Formula

C₉H₁₂N₂O₅S

CAS No.

60084-10-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(N)C1=CSC([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (480.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8422 mL	19.2108 mL	38.4216 mL
5 mM	0.7684 mL	3.8422 mL	7.6843 mL
10 mM	0.3842 mL	1.9211 mL	3.8422 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.84%

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Data Sheet (270 KB) SDS (393 KB)

COA (249 KB) HNMR (273 KB) RP-HPLC (238 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Tricot G, Jayaram HN, Weber G, Hoffman R. Tiazofurin: biological effects and clinical uses. Int J Cell Cloning. 1990;8(3):161-170. [Content Brief]

[2]. Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57(1-2):13-23. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8422 mL	19.2108 mL	38.4216 mL	96.0541 mL
	5 mM	0.7684 mL	3.8422 mL	7.6843 mL	19.2108 mL
	10 mM	0.3842 mL	1.9211 mL	3.8422 mL	9.6054 mL
	15 mM	0.2561 mL	1.2807 mL	2.5614 mL	6.4036 mL
	20 mM	0.1921 mL	0.9605 mL	1.9211 mL	4.8027 mL
	25 mM	0.1537 mL	0.7684 mL	1.5369 mL	3.8422 mL
	30 mM	0.1281 mL	0.6404 mL	1.2807 mL	3.2018 mL
	40 mM	0.0961 mL	0.4803 mL	0.9605 mL	2.4014 mL
	50 mM	0.0768 mL	0.3842 mL	0.7684 mL	1.9211 mL
	60 mM	0.0640 mL	0.3202 mL	0.6404 mL	1.6009 mL
	80 mM	0.0480 mL	0.2401 mL	0.4803 mL	1.2007 mL
	100 mM	0.0384 mL	0.1921 mL	0.3842 mL	0.9605 mL

Tiazofurin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tiazofurin60084-10-8NSC 286193 RiboxamideNSC286193NSC-286193Nucleoside Antimetabolite/AnalogOrthopoxvirusInhibitorinhibitorinhibit

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Tiazofurin (Synonyms: NSC 286193; Riboxamide)

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Complete Stock Solution Preparation Table

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