2. PROTAC Immunology/Inflammation
  3. PROTAC Linkers Toll-like Receptor (TLR)
  4. TLR4-IN-C34-C2-amide-C6-OH

TLR4-IN-C34-C2-amide-C6-OH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.

For research use only. We do not sell to patients.

TLR4-IN-C34-C2-amide-C6-OH Chemical Structure

TLR4-IN-C34-C2-amide-C6-OH Chemical Structure

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5 mg USD 570 In-stock
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Based on 1 publication(s) in Google Scholar

TLR4-IN-C34-C2-amide-C6-OH Related Antibodies

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Description

TLR4-IN-C34-C2-amide-C6-OH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1].

IC50 & Target[1]

Alkyl/ether

 

TLR4

 

Molecular Weight

546.61

Formula

C25H42N2O11
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(NCCCCCCO)CCCCO[C@H]1[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (274.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8295 mL 9.1473 mL 18.2946 mL
5 mM 0.3659 mL 1.8295 mL 3.6589 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8295 mL 9.1473 mL 18.2946 mL 45.7364 mL
5 mM 0.3659 mL 1.8295 mL 3.6589 mL 9.1473 mL
10 mM 0.1829 mL 0.9147 mL 1.8295 mL 4.5736 mL
15 mM 0.1220 mL 0.6098 mL 1.2196 mL 3.0491 mL
20 mM 0.0915 mL 0.4574 mL 0.9147 mL 2.2868 mL
25 mM 0.0732 mL 0.3659 mL 0.7318 mL 1.8295 mL
30 mM 0.0610 mL 0.3049 mL 0.6098 mL 1.5245 mL
40 mM 0.0457 mL 0.2287 mL 0.4574 mL 1.1434 mL
50 mM 0.0366 mL 0.1829 mL 0.3659 mL 0.9147 mL
60 mM 0.0305 mL 0.1525 mL 0.3049 mL 0.7623 mL
80 mM 0.0229 mL 0.1143 mL 0.2287 mL 0.5717 mL
100 mM 0.0183 mL 0.0915 mL 0.1829 mL 0.4574 mL
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TLR4-IN-C34-C2-amide-C6-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR4-IN-C34-C2-amide-C6-OHPROTAC LinkersToll-like Receptor (TLR)TLR4enterocytesmacrophagesinflammationenterocolitislinkerInhibitorinhibitorinhibit

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TLR4-IN-C34-C2-amide-C6-OH
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