2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. TMPRSS6-IN-1 TFA

TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice.

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TMPRSS6-IN-1 TFA Chemical Structure

TMPRSS6-IN-1 TFA Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of TMPRSS6-IN-1 TFA:

TMPRSS6-IN-1 TFA Related Antibodies

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Description

TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice[1].

Molecular Weight

790.88

Formula

C35H41F3N8O6S2
Appearance

Solid

SMILES

NC(NCCC[C@H](NC([C@@H](NC([C@@H](NC(CCC1=CC=CC=C1)=O)CC2=CSC=N2)=O)C(C)C)=O)C(C3=NC4=C(S3)C=CC=C4)=O)=N.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (158.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2644 mL 6.3221 mL 12.6441 mL
5 mM 0.2529 mL 1.2644 mL 2.5288 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2644 mL 6.3221 mL 12.6441 mL 31.6104 mL
5 mM 0.2529 mL 1.2644 mL 2.5288 mL 6.3221 mL
10 mM 0.1264 mL 0.6322 mL 1.2644 mL 3.1610 mL
15 mM 0.0843 mL 0.4215 mL 0.8429 mL 2.1074 mL
20 mM 0.0632 mL 0.3161 mL 0.6322 mL 1.5805 mL
25 mM 0.0506 mL 0.2529 mL 0.5058 mL 1.2644 mL
30 mM 0.0421 mL 0.2107 mL 0.4215 mL 1.0537 mL
40 mM 0.0316 mL 0.1581 mL 0.3161 mL 0.7903 mL
50 mM 0.0253 mL 0.1264 mL 0.2529 mL 0.6322 mL
60 mM 0.0211 mL 0.1054 mL 0.2107 mL 0.5268 mL
80 mM 0.0158 mL 0.0790 mL 0.1581 mL 0.3951 mL
100 mM 0.0126 mL 0.0632 mL 0.1264 mL 0.3161 mL
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TMPRSS6-IN-1 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TMPRSS6-IN-1Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesInhibitorinhibitorinhibit

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