2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Tofersen sodium

Tofersen sodium  (Synonyms: BIIB067 sodium; ISIS-SOD1Rx sodium)

Cat. No.: HY-132580A Purity: 97.19%
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Tofersen sodium is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen sodium can be used for the research of amyotrophic lateral sclerosis (ALS).

For research use only. We do not sell to patients.

DNA, d([2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2- methoxyethyl)]rG-sp-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]rA-sp-Tsp-A-sp-m5C-sp-A-sp-T-sp-T-sp-T-sp-m5C-sp-T-sp-A-sp-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-sp-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]m5rU), sodium salt

Tofersen sodium Chemical Structure

CAS No. : 1898254-60-8

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Based on 1 publication(s) in Google Scholar

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Description

Tofersen sodium is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen sodium can be used for the research of amyotrophic lateral sclerosis (ALS)[1].

Molecular Weight

7546.00

Formula

C230H298N72Na19O123P19S15
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

[Tofersen (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Purity & Documentation
References
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Tofersen sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tofersen1898254-60-8BIIB067ISIS-SOD1RxBIIB 067BIIB-067DNA/RNA SynthesisantisenseoligonucleotideRNase HSOD1amyotrophiclateralsclerosisALSInhibitorinhibitorinhibit

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