2. Anti-infection
  3. Parasite Antibiotic
  4. Toltrazuril

Toltrazuril  (Synonyms: BAY-i 9142)

Cat. No.: HY-B0175 Purity: 99.64%
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Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites.

For research use only. We do not sell to patients.

Toltrazuril Chemical Structure

Toltrazuril Chemical Structure

CAS No. : 69004-03-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 61 In-stock
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Solid
500 mg USD 55 In-stock
1 g USD 68 In-stock
5 g USD 283 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Toltrazuril:

Toltrazuril Related Antibodies

Top Publications Citing Use of Products

View All Parasite Isoform Specific Products:

View All Isoforms
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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View All Isoforms
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites.

IC50 & Target

Coccidia

 

In Vitro

Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites. Toltrazuril induces changes in the fine structure of coccidian development stages that are mainly due to a swelling of the endoplasmatic reticulum and of the Golgi apparatus and to abnormalities in the peri-nuclear space, disturbance in nuclear division. Treated with toltrazuril showed a considerably lower mean opg to that of group C (5.78 opg versus 144.62 opg) (p < 0.05) and a FOCR of 97.7 %. The higher efficacy (99.23 %) was observed at 15 days post treatment; however, the average efficacy of the drug remained extremely high (> 90 %) for all the study.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Toltrazuril Related Antibodies
Molecular Weight

425.38

Formula

C18H14F3N3O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C1=CC=C(OC2=CC=C(SC(F)(F)F)C=C2)C(C)=C1)C(N3)=O)N(C)C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 130 mg/mL (305.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3508 mL 11.7542 mL 23.5084 mL
5 mM 0.4702 mL 2.3508 mL 4.7017 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 3.25 mg/mL (7.64 mM); Clear solution

    This protocol yields a clear solution of ≥ 3.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3508 mL 11.7542 mL 23.5084 mL 58.7710 mL
5 mM 0.4702 mL 2.3508 mL 4.7017 mL 11.7542 mL
10 mM 0.2351 mL 1.1754 mL 2.3508 mL 5.8771 mL
15 mM 0.1567 mL 0.7836 mL 1.5672 mL 3.9181 mL
20 mM 0.1175 mL 0.5877 mL 1.1754 mL 2.9385 mL
25 mM 0.0940 mL 0.4702 mL 0.9403 mL 2.3508 mL
30 mM 0.0784 mL 0.3918 mL 0.7836 mL 1.9590 mL
40 mM 0.0588 mL 0.2939 mL 0.5877 mL 1.4693 mL
50 mM 0.0470 mL 0.2351 mL 0.4702 mL 1.1754 mL
60 mM 0.0392 mL 0.1959 mL 0.3918 mL 0.9795 mL
80 mM 0.0294 mL 0.1469 mL 0.2939 mL 0.7346 mL
100 mM 0.0235 mL 0.1175 mL 0.2351 mL 0.5877 mL
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Toltrazuril Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Toltrazuril69004-03-1BAY-i 9142ParasiteAntibioticInhibitorinhibitorinhibit

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