2. Neuronal Signaling
  3. Huntingtin
  4. Tominersen sodium

Tominersen sodium  (Synonyms: RG6042 sodium; IONIS-HTTRx sodium)

Cat. No.: HY-132579A Purity: 97.34%
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Tominersen sodium is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen sodium can be used for the research of Huntington’s disease (HD).

For research use only. We do not sell to patients.

DNA, d([2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]rG-sp-T-sp-A-sp-A-sp-m5C-sp-A-sp-T-sp-T-sp-G-spA-sp-m5C-sp-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-sp-[2'-O-(2-methoxyethyl)]m5rC), sodium salt

Tominersen sodium Chemical Structure

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1 mg USD 138 In-stock
5 mg USD 374 In-stock
10 mg USD 563 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Tominersen sodium is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen sodium can be used for the research of Huntington’s disease (HD)[1][2].

Molecular Weight

7517.39

Formula

C230H299N74Na20O122P19S13
Appearance

Solid

Color

Off-white to light yellow

SMILES

[Tominersen (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 97.34%

COA (244 KB) LCMS (650 KB)

Handling Instructions (2659 KB)
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Tominersen sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TominersenRG6042IONIS-HTTRxRG 6042RG-6042HuntingtinantisenseoligonucleotidehuntingtinHTT,brain atrophyInhibitorinhibitorinhibit

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