2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase IIα-IN-8

Topoisomerase IIα-IN-8 (compound 15) is a weak human DNA topoisomerase IIa (htIIa) inhibitor, with an IC50 of 462 ± 38.0 μM.

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Topoisomerase IIα-IN-8 Chemical Structure

Topoisomerase IIα-IN-8 Chemical Structure

CAS No. : 1251578-67-2

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Description

Topoisomerase IIα-IN-8 (compound 15) is a weak human DNA topoisomerase IIa (htIIa) inhibitor, with an IC50 of 462 ± 38.0 μM[1].

IC50 & Target

topoisomerase II alpha

 

Cellular Effect
Cell Line Type Value Description References
HEK293 GI50
> 100 μM
Compound: 3l
Antiproliferative activity against human HEK293 cells after 72 hrs by MTS assay
Antiproliferative activity against human HEK293 cells after 72 hrs by MTS assay
[PMID: 29684894]
HT-29 GI50
> 100 μM
Compound: 3l
Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
[PMID: 29684894]
Molecular Weight

314.32

Formula

C15H15FN6O
CAS No.
Appearance

Powder

SMILES

FC1=CC=C(C=C1)NC2=NC3=C(N=CN3)C(N4CCOCC4)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Topoisomerase IIα-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase IIα-IN-81251578-67-2TopoisomeraseInhibitorinhibitorinhibit

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