2. Apoptosis
  3. TNF Receptor
  4. Toralizumab

Toralizumab  (Synonyms: IDEC-131; Anti-Human CD40 ligand Recombinant Antibody)

Cat. No.: HY-P99325 Purity: 95.00%
COA

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Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab, a immunosuppressive agent, has the potential for active systemic lupus erythematosus (SLE) research.

For research use only. We do not sell to patients.

CAS No. : 252662-47-8

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1 mg USD 350 In-stock
5 mg USD 910 In-stock
10 mg USD 1450 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Toralizumab Related Antibodies

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab, a immunosuppressive agent, has the potential for active systemic lupus erythematosus (SLE) research[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
IC50 & Target[1][2]

CD40L

 

Molecular Weight

148.43 (kD)

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Toralizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation

Purity: 95.00%

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Toralizumab Related Classifications

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Toralizumab252662-47-8IDEC-131 Anti-Human CD40 ligand Recombinant AntibodyIDEC131IDEC 131TNF ReceptorTumor Necrosis Factor ReceptorTNFRHumanizedmonoclonal antibodymAbCD40LCD154gamma 1 heavy chainskappa light chainsT cellssystemic lupus erythematosusSLEInhibitorinhibitorinhibit

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