2. PI3K/Akt/mTOR
  3. PI3K Akt mTOR
  4. Toyaburgine

Toyaburgine is a unique isoquinoline compound that exhibits anti-tumor activity. It packs a punch by disrupting the PI3K/AKT/mTOR signaling pathway, causing significant morphological changes and cell death in MIA PaCa-2 cells. On top of that, it puts the brakes on cell migration and colony formation. This compound is showing a lot of promise in the realm of pancreatic cancer research.

For research use only. We do not sell to patients.

Toyaburgine Chemical Structure

Toyaburgine Chemical Structure

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Toyaburgine Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

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mTOR mTORC1 mTORC2

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Description

Toyaburgine is a unique isoquinoline compound that exhibits anti-tumor activity. It packs a punch by disrupting the PI3K/AKT/mTOR signaling pathway, causing significant morphological changes and cell death in MIA PaCa-2 cells. On top of that, it puts the brakes on cell migration and colony formation. This compound is showing a lot of promise in the realm of pancreatic cancer research[1].

Molecular Weight

564.39

Formula

C27H25BrF3NO4
SMILES

BrC(C=C1)=CC=C1C(C=C2)=CC=C2[N+]([C@@H](C)C3)=C(C)C4=C3C=C(OC)C=C4OC.O=C([O-])C(F)(F)F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Toyaburgine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ToyaburginePI3KAktmTORPhosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinInhibitorinhibitorinhibit

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