2. Immunology/Inflammation
  3. Interleukin Related
  4. Tozorakimab

Tozorakimab  (Synonyms: MEDI-3506)

Cat. No.: HY-P99550 Purity: 98.82%
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COA
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Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33. Tozorakimab reduces inflammation and epithelial dysfunction. Tozorakimab can be used to research chronic obstructive pulmonary disease.

For research use only. We do not sell to patients.

CAS No. : 2376858-66-9

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Based on 1 publication(s) in Google Scholar

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33. Tozorakimab reduces inflammation and epithelial dysfunction. Tozorakimab can be used to research chronic obstructive pulmonary disease[1].

Isotype

Human IgG1 lambda1
Recommend Isotype Controls
Species

Humanized
In Vivo

Tozorakimab (0.1-10 mg/kg, i.p., once time) inhibits IL-5 levels in bronchoalveolar lavage fluid of humanized IL-33 genetically modified mice in dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Tozorakimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
Biological Activity
  • Immobilized Human IL-33 Protein can bind Tozorakimab. The EC50 for this effect is 3.21 ng/mL.
Purity & Documentation

Purity: 98.82%

SDS (251 KB)

COA (231 KB) SDS-PAGE (77 KB) SEC-HPLC (126 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Tozorakimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tozorakimab2376858-66-9MEDI-3506MEDI3506MEDI 3506Interleukin RelatedILinterleukin-33IgG1inflammationepithelial dysfunctionchronic obstructiveInhibitorinhibitorinhibit

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