2. Immunology/Inflammation
  3. Interleukin Related
  4. Tozorakimab

Tozorakimab  (Synonyms: MEDI-3506)

Cat. No.: HY-P99550 Purity: 98.82%
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COA
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Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33. Tozorakimab reduces inflammation and epithelial dysfunction. Tozorakimab can be used to research chronic obstructive pulmonary disease.

For research use only. We do not sell to patients.

CAS No. : 2376858-66-9

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Based on 1 publication(s) in Google Scholar

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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  • Purity & Documentation

  • References

  • Customer Review

Description

Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33. Tozorakimab reduces inflammation and epithelial dysfunction. Tozorakimab can be used to research chronic obstructive pulmonary disease[1].

Isotype

Human IgG1 lambda1
Recommend Isotype Controls
Species

Humanized
In Vivo

Tozorakimab (0.1-10 mg/kg, i.p., once time) inhibits IL-5 levels in bronchoalveolar lavage fluid of humanized IL-33 genetically modified mice in dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

144660.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Tozorakimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
Biological Activity
  • Immobilized Human IL-33 Protein can bind Tozorakimab. The EC50 for this effect is 3.21 ng/mL.
Purity & Documentation

Purity: 98.82%

SDS (251 KB)

COA (231 KB) SDS-PAGE (77 KB) SEC-HPLC (126 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Tozorakimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tozorakimab2376858-66-9MEDI-3506MEDI3506MEDI 3506Interleukin RelatedILinterleukin-33IgG1inflammationepithelial dysfunctionchronic obstructiveInhibitorinhibitorinhibit

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