2. Apoptosis Metabolic Enzyme/Protease
  3. RIP kinase Ser/Thr Protease
  4. TP-030-2

TP-030-2 is a RIPK1 inhibitor (human Ki=0.43 nM; mouse IC50=100 nM).

For research use only. We do not sell to patients.

TP-030-2 Chemical Structure

TP-030-2 Chemical Structure

CAS No. : 2095514-84-2

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5 mg USD 590 In-stock
10 mg USD 945 In-stock
25 mg USD 1890 In-stock
50 mg USD 3025 In-stock
100 mg USD 4840 In-stock
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Based on 1 publication(s) in Google Scholar

TP-030-2 Related Antibodies

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Description

TP-030-2 is a RIPK1 inhibitor (human Ki=0.43 nM; mouse IC50=100 nM)[1][2].

In Vitro

TP-030-2 shows inhibiton in HT29 with IC50=1.3 nM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TP-030-2 Related Antibodies
Molecular Weight

481.34

Formula

C23H21BrN4O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C2=NN(CC3=CC=CC=C3)C(Br)=C2CCN1[C@@H]4C(N(C5=CC=CC=C5OC4)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (207.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0775 mL 10.3877 mL 20.7753 mL
5 mM 0.4155 mL 2.0775 mL 4.1551 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0775 mL 10.3877 mL 20.7753 mL 51.9383 mL
5 mM 0.4155 mL 2.0775 mL 4.1551 mL 10.3877 mL
10 mM 0.2078 mL 1.0388 mL 2.0775 mL 5.1938 mL
15 mM 0.1385 mL 0.6925 mL 1.3850 mL 3.4626 mL
20 mM 0.1039 mL 0.5194 mL 1.0388 mL 2.5969 mL
25 mM 0.0831 mL 0.4155 mL 0.8310 mL 2.0775 mL
30 mM 0.0693 mL 0.3463 mL 0.6925 mL 1.7313 mL
40 mM 0.0519 mL 0.2597 mL 0.5194 mL 1.2985 mL
50 mM 0.0416 mL 0.2078 mL 0.4155 mL 1.0388 mL
60 mM 0.0346 mL 0.1731 mL 0.3463 mL 0.8656 mL
80 mM 0.0260 mL 0.1298 mL 0.2597 mL 0.6492 mL
100 mM 0.0208 mL 0.1039 mL 0.2078 mL 0.5194 mL
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TP-030-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TP-030-22095514-84-2RIP kinaseSer/Thr ProteaseReceptor-interacting protein kinasesRIPKSerine proteasesSerine endopeptidasesThreonine proteasesHT29Inhibitorinhibitorinhibit

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TP-030-2
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HY-148239
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