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  3. TP748

TP748,an isoxazole, is a key intermediate for fully synthetic tetracyclines.

For research use only. We do not sell to patients.

TP748 Chemical Structure

TP748 Chemical Structure

CAS No. : 951698-15-0

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Description

TP748,an isoxazole, is a key intermediate for fully synthetic tetracyclines[1].

In Vitro

A robust, cost effective and high yielding manufacturing process for enantiomerically enriched (S)-allylic amine 3, a key intermediate for fully synthetic tetracyclines have been developed[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

258.32

Formula

C15H18N2O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN(C)[C@H](C1=CC(OCC2=CC=CC=C2)=NO1)C=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (387.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8712 mL 19.3558 mL 38.7117 mL
5 mM 0.7742 mL 3.8712 mL 7.7423 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8712 mL 19.3558 mL 38.7117 mL 96.7792 mL
5 mM 0.7742 mL 3.8712 mL 7.7423 mL 19.3558 mL
10 mM 0.3871 mL 1.9356 mL 3.8712 mL 9.6779 mL
15 mM 0.2581 mL 1.2904 mL 2.5808 mL 6.4519 mL
20 mM 0.1936 mL 0.9678 mL 1.9356 mL 4.8390 mL
25 mM 0.1548 mL 0.7742 mL 1.5485 mL 3.8712 mL
30 mM 0.1290 mL 0.6452 mL 1.2904 mL 3.2260 mL
40 mM 0.0968 mL 0.4839 mL 0.9678 mL 2.4195 mL
50 mM 0.0774 mL 0.3871 mL 0.7742 mL 1.9356 mL
60 mM 0.0645 mL 0.3226 mL 0.6452 mL 1.6130 mL
80 mM 0.0484 mL 0.2419 mL 0.4839 mL 1.2097 mL
100 mM 0.0387 mL 0.1936 mL 0.3871 mL 0.9678 mL
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TP748 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TP748
Cat. No.:
HY-135888
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