Transdermal Peptide Disulfide TFA (Synonyms: TD 1 Disulfide(peptide) TFA)

Name: Transdermal Peptide Disulfide TFA
Brand: MedChemExpress
SKU: HY-P1565A
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1565A Purity: 98.86%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to Na⁺/K⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide TFA can enhance the transdermal delivery of many macromolecules.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Transdermal Peptide Disulfide TFA Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Transdermal Peptide Disulfide TFA:

Transdermal Peptide Disulfide Get quote

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References
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Description

In Vitro

In the presence of Transdermal Peptide Disulfide, because of the specific binding of Transdermal Peptide Disulfide to ATP1B1, cells will upregulate the level of ATP1B1 to maintain function and structure; as a result, the expression of ATP1B1 increases. However, as time goes on, some Transdermal Peptide Disulfide molecules may be transported into cells by endocytosis; consequently, the expression of ATP1B1 then decreases. The interaction between Transdermal Peptide Disulfide and ATP1B1 changes not only the expression of ATP1B1, but also the localization of ATP1B1 and then the structure of the epidermal layer. This interaction can be attenuated by inhibitors or competitors, which would result in the reduced delivery of macromolecular drugs across the skin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1175.17

Formula

C₄₂H₆₅F₃N₁₄O₁₈S₂

Appearance

Solid

Color

White to off-white

Sequence Shortening

ACSSSPSKHCG (Disulfide bridge: Cys2-Cys10)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (85.09 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8509 mL	4.2547 mL	8.5094 mL
5 mM	0.1702 mL	0.8509 mL	1.7019 mL
10 mM	0.0851 mL	0.4255 mL	0.8509 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (85.09 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.86%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (253 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Wang C, et al. Role of the Na(+)/K(+)-ATPase beta-subunit in peptide-mediated transdermal drug delivery. Mol Pharm. 2015 Apr 6;12(4):1259-67. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.8509 mL	4.2547 mL	8.5094 mL	21.2735 mL
	5 mM	0.1702 mL	0.8509 mL	1.7019 mL	4.2547 mL
	10 mM	0.0851 mL	0.4255 mL	0.8509 mL	2.1274 mL
	15 mM	0.0567 mL	0.2836 mL	0.5673 mL	1.4182 mL
	20 mM	0.0425 mL	0.2127 mL	0.4255 mL	1.0637 mL
	25 mM	0.0340 mL	0.1702 mL	0.3404 mL	0.8509 mL
	30 mM	0.0284 mL	0.1418 mL	0.2836 mL	0.7091 mL
	40 mM	0.0213 mL	0.1064 mL	0.2127 mL	0.5318 mL
	50 mM	0.0170 mL	0.0851 mL	0.1702 mL	0.4255 mL
	60 mM	0.0142 mL	0.0709 mL	0.1418 mL	0.3546 mL
	80 mM	0.0106 mL	0.0532 mL	0.1064 mL	0.2659 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Transdermal Peptide Disulfide TFA Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Transdermal Peptide DisulfideTD 1 Disulfide(peptide)Na+/K+ ATPaseSodium potassium pumpInhibitorinhibitorinhibit

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Transdermal Peptide Disulfide TFA (Synonyms: TD 1 Disulfide(peptide) TFA)

Customer Review

Other Forms of Transdermal Peptide Disulfide TFA:

Transdermal Peptide Disulfide TFA Related Antibodies

Featured Recommendations

•Related Screening Libraries:

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Biological Activity

Purity & Documentation

References

Customer Review

Transdermal Peptide Disulfide TFA Related Antibodies

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Complete Stock Solution Preparation Table

Transdermal Peptide Disulfide TFA Related Classifications

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