2. GPCR/G Protein Metabolic Enzyme/Protease Neuronal Signaling Immunology/Inflammation
  3. Phosphodiesterase (PDE) Histamine Receptor
  4. Traxanox

Traxanox is an orally available diuretic that enhances phagocytosis of yeast granules by mouse peritoneal macrophages and rat peritoneal polymorphonuclear leukocytes in vitro. Traxanox inhibits IgE-mediated histamine release and cyclic AMP phosphodiesterase activity.Traxanox exhibits anti-inflammatory activity, as it inhibits the anaphylactoid reaction and reduces pleural fluid accumulation in experimental models of inflammation. Traxanox also demonstrates a synergistic effect when combined with hydrocortisone or indomethacin in suppressing adjuvant arthritis in rats.

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Traxanox Chemical Structure

Traxanox Chemical Structure

CAS No. : 58712-69-9

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Description

Traxanox is an orally available diuretic that enhances phagocytosis of yeast granules by mouse peritoneal macrophages and rat peritoneal polymorphonuclear leukocytes in vitro. Traxanox inhibits IgE-mediated histamine release and cyclic AMP phosphodiesterase activity.Traxanox exhibits anti-inflammatory activity, as it inhibits the anaphylactoid reaction and reduces pleural fluid accumulation in experimental models of inflammation. Traxanox also demonstrates a synergistic effect when combined with hydrocortisone or indomethacin in suppressing adjuvant arthritis in rats.

Molecular Weight

299.67

Formula

C13H6ClN5O2
CAS No.
SMILES

O=C1C2=CC=CN=C2OC3=C1C=C(C4=NN=NN4)C=C3Cl
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Purity & Documentation
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Traxanox Related Classifications

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Keywords:

Traxanox58712-69-9Phosphodiesterase (PDE)Histamine ReceptorInhibitorinhibitorinhibit

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