2. Immunology/Inflammation
  3. CTLA-4
  4. Tremelimumab

Tremelimumab  (Synonyms: Ticilimumab; CP-675206)

Cat. No.: HY-P9918 Purity: 99.50%
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Tremelimumab (Ticilimumab) is a fully human monoclonal antibody specific for cytotoxic T-lymphocyte antigen-4 (CTLA-4) and can be used for metastatic melanoma research.

For research use only. We do not sell to patients.

CAS No. : 745013-59-6

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Based on 1 publication(s) in Google Scholar

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Tremelimumab Related Antibodies

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Description

Tremelimumab (Ticilimumab) is a fully human monoclonal antibody specific for cytotoxic T-lymphocyte antigen-4 (CTLA-4) and can be used for metastatic melanoma research[1].

Isotype

Human IgG2 kappa
Recommend Isotype Controls
Species

Human
In Vitro

Tremelimumab (Ticilimumab) has a higher affinity for CTLA-4-Ig than for CD28-Ig and that the antibody is specific for cynomolgus monkeys and humans[1].
Tremelimumab does not bind to human leukocyte FcγR and does not trigger the release of cytokines avoiding the cytokine release syndrome, but increases the IL-2 production upon stimulation with the staphylococcal enterotoxin A in a concentration-dependent manner[1].
Tremelimumab enhances the IL-2 production in T-cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tremelimumab Related Antibodies
Clinical Trial
Molecular Weight

146400.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Tremelimumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Biological Activity
  • Flow cytometry analysis of CTLA4 overexpression CHOK1 cells labelling CTLA4 with Tremelimumab at 20 nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
  • Immobilized CTLA-4 Protein, Human can bind Tremelimumab. The EC50 for this effect is 1.69 ng/mL.
Purity & Documentation
References
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Tremelimumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tremelimumab745013-59-6Ticilimumab CP-675206CP675206CP 675206CP-675206CTLA-4Cytotoxic T-lymphocyte-associated protein 4CD152metastatic melanomafully humanized monoclonal antibodycytotoxic T-lymphocyte antigen-4Inhibitorinhibitorinhibit

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