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  3. Isotope-Labeled Compounds
  4. Treprostinil-d9

Treprostinil-d9  (Synonyms: UT-15-d9)

Cat. No.: HY-100441S2 Purity: 99.79%
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Treprostinil-d9 (UT-15-d9) is the deuterium-labeled Treprostinil (HY-100441). Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.

For research use only. We do not sell to patients.

Treprostinil-d<sub>9</sub> Chemical Structure

Treprostinil-d9 Chemical Structure

CAS No. : 2747918-14-3

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1 mg USD 540 In-stock
5 mg USD 1340 In-stock
10 mg USD 2150 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Treprostinil-d9:

Treprostinil-d9 Related Antibodies

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Description

Treprostinil-d9 (UT-15-d9) is the deuterium-labeled Treprostinil (HY-100441)[1]. Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.

IC50 & Target

EC50: 0.6±0.1 nM (DP1), 6.2±1.2 nM (EP2)[1]
In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Treprostinil-d9 Related Antibodies
Molecular Weight

399.57

Formula

C23H25D9O5
CAS No.
Unlabeled CAS

81846-19-7
Appearance

Solid

Color

White to off-white

SMILES

OC(COC1=CC=CC2=C1C[C@]([H])([C@@]3(C2)[H])C[C@H]([C@@H]3CC[C@H](CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])O)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (312.84 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5027 mL 12.5135 mL 25.0269 mL
5 mM 0.5005 mL 2.5027 mL 5.0054 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5027 mL 12.5135 mL 25.0269 mL 62.5673 mL
5 mM 0.5005 mL 2.5027 mL 5.0054 mL 12.5135 mL
10 mM 0.2503 mL 1.2513 mL 2.5027 mL 6.2567 mL
15 mM 0.1668 mL 0.8342 mL 1.6685 mL 4.1712 mL
20 mM 0.1251 mL 0.6257 mL 1.2513 mL 3.1284 mL
25 mM 0.1001 mL 0.5005 mL 1.0011 mL 2.5027 mL
30 mM 0.0834 mL 0.4171 mL 0.8342 mL 2.0856 mL
40 mM 0.0626 mL 0.3128 mL 0.6257 mL 1.5642 mL
50 mM 0.0501 mL 0.2503 mL 0.5005 mL 1.2513 mL
60 mM 0.0417 mL 0.2086 mL 0.4171 mL 1.0428 mL
80 mM 0.0313 mL 0.1564 mL 0.3128 mL 0.7821 mL
100 mM 0.0250 mL 0.1251 mL 0.2503 mL 0.6257 mL
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Treprostinil-d9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Treprostinil-d92747918-14-3UT-15-d9Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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