2. Cytoskeleton
  3. Dynamin
  4. Trimethyloctadecylammonium bromide

Trimethyloctadecylammonium bromide 

Cat. No.: HY-W013158 Purity: ≥98.0%
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Trimethyloctadecylammonium bromide is an inhibitor of dynamin, with an IC50 value of 1.9 μM for dynamin I. Trimethyloctadecylammonium bromide exhibits antibacterial activity against Staphylococcus aureus.

For research use only. We do not sell to patients.

Trimethyloctadecylammonium bromide Chemical Structure

Trimethyloctadecylammonium bromide Chemical Structure

CAS No. : 1120-02-1

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Trimethyloctadecylammonium bromide Related Antibodies

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Description

Trimethyloctadecylammonium bromide is an inhibitor of dynamin, with an IC50 value of 1.9 μM for dynamin I. Trimethyloctadecylammonium bromide exhibits antibacterial activity against Staphylococcus aureus[1][2].

IC50 & Target

IC50: 1.9 μM (Dynamin I)[1]
In Vitro

Trimethyloctadecylammonium bromide (1 μM-100 μM; 10 min) inhibits EGF-A488 endocytosis in COS-7 cells, with an IC50 value of 16 μM[1].
Trimethyloctadecylammonium bromide (30 μM; 10 min; 37 ℃) shows no effect on EGFR activation in A431 cells with insignificant EGFR autophosphorylation change[1].
Trimethyloctadecylammonium bromide (stearyl-) (1 nM-1 mM) inhibits Staphylococcus aureus with of 59.5 nM (CKD assay) and 0.33 mM (CMC assay), respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trimethyloctadecylammonium bromide Related Antibodies
Molecular Weight

392.51

Formula

C21H46BrN
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCCCC[N+](C)(C)C.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (25.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5477 mL 12.7385 mL 25.4771 mL
5 mM 0.5095 mL 2.5477 mL 5.0954 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5477 mL 12.7385 mL 25.4771 mL 63.6926 mL
5 mM 0.5095 mL 2.5477 mL 5.0954 mL 12.7385 mL
10 mM 0.2548 mL 1.2739 mL 2.5477 mL 6.3693 mL
15 mM 0.1698 mL 0.8492 mL 1.6985 mL 4.2462 mL
20 mM 0.1274 mL 0.6369 mL 1.2739 mL 3.1846 mL
25 mM 0.1019 mL 0.5095 mL 1.0191 mL 2.5477 mL
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Trimethyloctadecylammonium bromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trimethyloctadecylammonium1120-02-1DynaminStaphylococcus aureusantibacterial activityGTPaseammoniumEGF-A488Inhibitorinhibitorinhibit

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