2. Neuronal Signaling Protein Tyrosine Kinase/RTK Stem Cell/Wnt MAPK/ERK Pathway PI3K/Akt/mTOR Apoptosis
  3. Trk Receptor ERK PI3K Apoptosis
  4. TRK-IN-30

TRK-IN-30 (Compound C11) is the inhibitor for tropomyosin receptor kinase (TRK) that inhibits TRKA, TRKB and TRKC and drug resistant mutant TRKAG595R with an IC50 of 1.8, 0.98, 3.8, and 54 nM, respectively. TRK-IN-30 inhibits the activation of the downstream PI3K/AKT and MEK/ERK signaling pathways. TRK-IN-30 inhibits the colony formation and cell migration of Km-12, arrests the cell cycle at G0/G1 phase, and induces apoptosis in Km-12.

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TRK-IN-30 Chemical Structure

TRK-IN-30 Chemical Structure

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TRK-IN-30 Related Antibodies

Top Publications Citing Use of Products

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TrkA TrkB TrkC Trk

View All ERK Isoform Specific Products:

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ERK ERK1 ERK2 ERK5 ERK8

View All PI3K Isoform Specific Products:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

TRK-IN-30 (Compound C11) is the inhibitor for tropomyosin receptor kinase (TRK) that inhibits TRKA, TRKB and TRKC and drug resistant mutant TRKAG595R with an IC50 of 1.8, 0.98, 3.8, and 54 nM, respectively. TRK-IN-30 inhibits the activation of the downstream PI3K/AKT and MEK/ERK signaling pathways. TRK-IN-30 inhibits the colony formation and cell migration of Km-12, arrests the cell cycle at G0/G1 phase, and induces apoptosis in Km-12[1].

Molecular Weight

427.46

Formula

C24H21N5O3
SMILES

NC1=C(C(NC2=CC(OC)=C(OC)C=C2)=O)C=CC=C1NC3=CC(NC=C4C#N)=C4C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TRK-IN-30 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRK-IN-30Trk ReceptorERKPI3KApoptosisTropomyosin related kinase receptor Extracellular signal regulated kinasesPhosphoinositide 3-kinaseKm-12Inhibitorinhibitorinhibit

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