2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Tropicamide-d3

Tropicamide-d3  (Synonyms: Ro 1-7683-d3)

Cat. No.: HY-B0321S Purity: 99.10%
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Tropicamide-d3 is the deuterium labeled Tropicamide[1]. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops[2][3].

For research use only. We do not sell to patients.

Tropicamide-d<sub>3</sub> Chemical Structure

Tropicamide-d3 Chemical Structure

CAS No. : 2673270-13-6

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5 mg USD 980 In-stock
10 mg USD 1600 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Tropicamide-d3:

Tropicamide-d3 Related Antibodies

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Description

Tropicamide-d3 is the deuterium labeled Tropicamide[1]. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops[2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tropicamide-d3 Related Antibodies
Molecular Weight

287.37

Formula

C17H17D3N2O2
CAS No.
Unlabeled CAS

1508-75-4
Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])CN(CC1=CC=NC=C1)C(C(C2=CC=CC=C2)CO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 30 mg/mL (104.40 mM)

DMSO : ≥ 30 mg/mL (104.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 30 mg/mL (104.40 mM)

DMSO : ≥ 30 mg/mL (104.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 30 mg/mL (104.40 mM)

DMF : ≥ 30 mg/mL (104.40 mM)

Ethanol:PBS(pH 7.2) (1:1) : ≥ 0.5 mg/mL (1.74 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4798 mL 17.3992 mL 34.7983 mL
5 mM 0.6960 mL 3.4798 mL 6.9597 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol:PBS(pH 7.2) (1:1) / Ethanol / DMSO / DMF / DMSO / Ethanol / DMF 1 mM 3.4798 mL 17.3992 mL 34.7983 mL 86.9959 mL
Ethanol / DMSO / DMF / DMSO / Ethanol / DMF 5 mM 0.6960 mL 3.4798 mL 6.9597 mL 17.3992 mL
10 mM 0.3480 mL 1.7399 mL 3.4798 mL 8.6996 mL
15 mM 0.2320 mL 1.1599 mL 2.3199 mL 5.7997 mL
20 mM 0.1740 mL 0.8700 mL 1.7399 mL 4.3498 mL
25 mM 0.1392 mL 0.6960 mL 1.3919 mL 3.4798 mL
30 mM 0.1160 mL 0.5800 mL 1.1599 mL 2.8999 mL
40 mM 0.0870 mL 0.4350 mL 0.8700 mL 2.1749 mL
50 mM 0.0696 mL 0.3480 mL 0.6960 mL 1.7399 mL
60 mM 0.0580 mL 0.2900 mL 0.5800 mL 1.4499 mL
80 mM 0.0435 mL 0.2175 mL 0.4350 mL 1.0874 mL
100 mM 0.0348 mL 0.1740 mL 0.3480 mL 0.8700 mL
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Tropicamide-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tropicamide-d32673270-13-6Ro 1-7683-d3mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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