2. GPCR/G Protein
  3. Angiotensin Receptor
  4. TRV055 hydrochloride

TRV055 hydrochloride, a G-protein-biased agonist, is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 hydrochloride is efficacious in stimulating cellular Gq-mediated signaling.

For research use only. We do not sell to patients.

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TRV055 hydrochloride Chemical Structure

TRV055 hydrochloride Chemical Structure

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5 mg USD 150 In-stock
10 mg USD 250 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of TRV055 hydrochloride:

TRV055 hydrochloride Related Antibodies

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Description

TRV055 hydrochloride, a G-protein-biased agonist, is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 hydrochloride is efficacious in stimulating cellular Gq-mediated signaling[1].

IC50 & Target[1]

Angiotensin II Type 1

 

Molecular Weight

868.42

Formula

C42H58ClN9O9
Appearance

Solid

Color

White to off-white

Sequence Shortening

GVYIHPF
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (57.58 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1515 mL 5.7576 mL 11.5152 mL
5 mM 0.2303 mL 1.1515 mL 2.3030 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1515 mL 5.7576 mL 11.5152 mL 28.7879 mL
5 mM 0.2303 mL 1.1515 mL 2.3030 mL 5.7576 mL
10 mM 0.1152 mL 0.5758 mL 1.1515 mL 2.8788 mL
15 mM 0.0768 mL 0.3838 mL 0.7677 mL 1.9192 mL
20 mM 0.0576 mL 0.2879 mL 0.5758 mL 1.4394 mL
25 mM 0.0461 mL 0.2303 mL 0.4606 mL 1.1515 mL
30 mM 0.0384 mL 0.1919 mL 0.3838 mL 0.9596 mL
40 mM 0.0288 mL 0.1439 mL 0.2879 mL 0.7197 mL
50 mM 0.0230 mL 0.1152 mL 0.2303 mL 0.5758 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TRV055 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRV055TRV 055TRV-055Angiotensin ReceptorAT1RGPCRGq-biasedligandInhibitorinhibitorinhibit

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