2. GPCR/G Protein
  3. Angiotensin Receptor
  4. TRV055

TRV055, a G-protein-biased agonist, is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TRV055 Chemical Structure

TRV055 Chemical Structure

CAS No. : 25849-90-5

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5 mg USD 150 In-stock
10 mg USD 250 In-stock
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Based on 1 publication(s) in Google Scholar

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TRV055 Related Antibodies

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Description

TRV055, a G-protein-biased agonist, is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling[1].

IC50 & Target[1]

Angiotensin II Type 1

 

Molecular Weight

831.96

Formula

C42H57N9O9
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

GVYIHPF
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (40.06 mM; ultrasonic and adjust pH to 2 with 1M HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2020 mL 6.0099 mL 12.0198 mL
5 mM 0.2404 mL 1.2020 mL 2.4040 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.2020 mL 6.0099 mL 12.0198 mL 30.0495 mL
5 mM 0.2404 mL 1.2020 mL 2.4040 mL 6.0099 mL
10 mM 0.1202 mL 0.6010 mL 1.2020 mL 3.0050 mL
15 mM 0.0801 mL 0.4007 mL 0.8013 mL 2.0033 mL
20 mM 0.0601 mL 0.3005 mL 0.6010 mL 1.5025 mL
25 mM 0.0481 mL 0.2404 mL 0.4808 mL 1.2020 mL
30 mM 0.0401 mL 0.2003 mL 0.4007 mL 1.0017 mL
40 mM 0.0300 mL 0.1502 mL 0.3005 mL 0.7512 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TRV055 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRV05525849-90-5TRV 055TRV-055Angiotensin ReceptorAT1RGPCRGq-biasedligandInhibitorinhibitorinhibit

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