Tulisokibart (Synonyms: PRA023; PRA-023)

Cat. No.: HY-P990007 Purity: 99.00%: FAQs
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Tulisokibart (PRA023) is a humanized IgG1-κ monoclonal antibody targeting to TNFSF15/TL1A. Tulisokibart can be used to study a variety of inflammatory/fibrotic diseases, such as Crohn's Disease (CD).

For research use only. We do not sell to patients.

CAS No. : 2648504-55-4

Size	Price	Stock	Quantity
1 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1250	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Purity & Documentation
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Description	Tulisokibart (PRA023) is a humanized IgG1-κ monoclonal antibody targeting to TNFSF15/TL1A. Tulisokibart can be used to study a variety of inflammatory/fibrotic diseases, such as Crohn's Disease (CD)^[1]^[2].
Isotype	Human IgG1 kappa
Recommend Isotype Controls	Human IgG1 kappa, Isotype Control
Species	Humanized
CAS No.	2648504-55-4
Appearance	Liquid
Color	Colorless to light yellow
SMILES	[Tulisokibart]
Shipping	Shipping with dry ice.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Format	Human IgG1 kappa
Biological Activity	Loaded Tulisokibart on AHC2 biosensor, can bind TL1A/TNFSF15 Protein, Human (HY-P71913) with an affinity constant of 3.693E-10 M as determined in BLI assay.
Purity & Documentation	Purity: 99.00% Select Batch: Data Sheet (256 KB) SDS (251 KB) COA (232 KB) SDS-PAGE (116 KB) SEC-HPLC (171 KB) Inhibitory Antibodies User Guide (602 KB)
References	[1]. Feagan B G, Sands B, Siegel C A, et al. DOP87 The Anti-TL1A Antibody PRA023 Demonstrated Proof-of-Concept in Crohn’s Disease: Phase 2a APOLLO-CD Study Results[J]. Journal of Crohn's and Colitis, 2023, 17(Supplement_1): i162-i164. [2]. Tulisokibart. IMGT/mAb-DB. [3]. B Sands, et al. OP40 PRA023 Demonstrated Efficacy and Favorable Safety as Induction Therapy for Moderately to Severely Active UC: Phase 2 ARTEMIS-UC Study Results, Journal of Crohn's and Colitis, Volume 17, Issue Supplement_1, February 2023, Pages i56–i59

Tulisokibart Related Classifications

Inflammation/Immunology

Inhibitory Antibodies

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tulisokibart2648504-55-4PRA023 PRA-023PRA 023PRA-023TNF ReceptorTumor Necrosis Factor ReceptorTNFRmononuclearCrohns diseaseInhibitorinhibitorinhibit

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