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Tusamitamab is an IgG1 monoclonal antibody that targets CEACAM5. Tusamitamab can be used to synthesize Tusamitamab ravtansine (SAR408701), which is a first-in-class humanized antibody-drug conjugate (ADC) that combines Tusamitamab and DM4 (a potent maytansine derivative).

For research use only. We do not sell to patients.

CAS No. : 2349294-95-5

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1 mg USD 250 In-stock
5 mg USD 715 In-stock
10 mg USD 1145 In-stock
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Based on 1 publication(s) in Google Scholar

Tusamitamab Related Antibodies

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Description

Tusamitamab is an IgG1 monoclonal antibody that targets CEACAM5. Tusamitamab can be used to synthesize Tusamitamab ravtansine (SAR408701), which is a first-in-class humanized antibody-drug conjugate (ADC) that combines Tusamitamab and DM4 (a potent maytansine derivative)[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Chimeric
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Tusamitamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded Tusamitamab on AHC2 biosensor, can bind CEACAM5 Protein, Human (HEK293, His, solution, HY-P75356) with an affinity constant of 6.031E-09 M as determined in BLI assay.
  • Immobilized CEACAM5 Protein, Human can bind Tusamitamab. The EC50 for this effect is 4.02 ng/mL.
Purity & Documentation

Purity: 95.30%

COA (231 KB) SDS-PAGE (282 KB) SEC-HPLC (490 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Tusamitamab Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tusamitamab2349294-95-5OthersIgG1 monoclonal antibodytargets CEACAM5Tusamitamab ravtansineantibody-drug conjugateADCInhibitorinhibitorinhibit

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