[Tyr0] Gastric Inhibitory Peptide (23-42), human 

[Tyr0] Gastric Inhibitory Peptide (23-42), human, a glucose-dependent insulinotropic polypeptide (GIP), is a weak inhibitor of gastric acid secretion that also stimulates insulin secretion. [Tyr0] Gastric Inhibitory Peptide (23-42), human can be used in diabetes, obesity research^[1][2].

GIPR^-/- mice have higher blood glucose levels and impaired initial insulin response after oral glucose loading. In GIPR^+/+ mice, a high-fat diet did not increase postprandial intake blood glucose levels, whereas it significantly increased in GIPR^-/- mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2584.93

C₁₁₉H₁₈₂N₃₄O₃₁

121765-67-1

YVNWLLAQKGKKNDWKHNITQ

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• [1]. LaPelusa A, et al. Biochemistry, Bombesin[M]//StatPearls [Internet]. StatPearls Publishing, 2021.

  [2]. K Miyawaki, et al. Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14843-7.  [Content Brief]