2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. Tyrosinase-IN-13

Tyrosinase-IN-13 (compound 3c), a derivative of Flurbiprofen (HY-10582), is a potent, non-competitive tyrosinase inhibitor (IC50=68 μM; Ki=36.3 μM). Tyrosinase-IN-13 is cytotoxic against hepatocellular carcinoma (HepG2), colorectal cancer (HT-29), and melanoma (B16F10).

For research use only. We do not sell to patients.

Tyrosinase-IN-13 Chemical Structure

Tyrosinase-IN-13 Chemical Structure

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Tyrosinase-IN-13 Related Antibodies

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Description

Tyrosinase-IN-13 (compound 3c), a derivative of Flurbiprofen (HY-10582), is a potent, non-competitive tyrosinase inhibitor (IC50=68 μM; Ki=36.3 μM). Tyrosinase-IN-13 is cytotoxic against hepatocellular carcinoma (HepG2), colorectal cancer (HT-29), and melanoma (B16F10)[1].

IC50 & Target

IC50: 68 μM (Tyrosinase)[1]
Molecular Weight

452.93

Formula

C23H18ClFN4OS
SMILES

FC1=C(C2=CC=CC=C2)C=CC(C(C)C3=NN=C(NC(NC4=CC(Cl)=CC=C4)=O)S3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tyrosinase-IN-13 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyrosinase-IN-13Tyrosinasecytotoxcityflurbiprofenmolecular dockingthiadiazole ringtyrosinase inhibitionureaInhibitorinhibitorinhibit

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Cat. No.:
HY-155240
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