2. Metabolic Enzyme/Protease Apoptosis Cell Cycle/DNA Damage
  3. Proteasome Apoptosis Deubiquitinase
  4. Ub4ix

Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Ub4ix Chemical Structure

Ub4ix Chemical Structure

CAS No. : 2396736-46-0

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Based on 1 publication(s) in Google Scholar

Ub4ix Related Antibodies

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View All Deubiquitinase Isoform Specific Products:

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USP1 USP2 USP7 USP8 USP30 UCHL1

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Description

Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM[1][2].
Molecular Weight

1767.91

Formula

C84H106N18O23S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

cyclo(Ac-{d-Trp}-Leu-Tyr-Leu-Asp-Asp-Ser-Gly-Asp-Trp-Trp-Ile-Cys)-Gly-NH2, cyclized via thioether
Sequence Shortening

cyclo(Ac-{d-Trp}-LYLDDSGDWWIC)-G-NH2, cyclized via thioether
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (56.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5656 mL 2.8282 mL 5.6564 mL
5 mM 0.1131 mL 0.5656 mL 1.1313 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5656 mL 2.8282 mL 5.6564 mL 14.1410 mL
5 mM 0.1131 mL 0.5656 mL 1.1313 mL 2.8282 mL
10 mM 0.0566 mL 0.2828 mL 0.5656 mL 1.4141 mL
15 mM 0.0377 mL 0.1885 mL 0.3771 mL 0.9427 mL
20 mM 0.0283 mL 0.1414 mL 0.2828 mL 0.7070 mL
25 mM 0.0226 mL 0.1131 mL 0.2263 mL 0.5656 mL
30 mM 0.0189 mL 0.0943 mL 0.1885 mL 0.4714 mL
40 mM 0.0141 mL 0.0707 mL 0.1414 mL 0.3535 mL
50 mM 0.0113 mL 0.0566 mL 0.1131 mL 0.2828 mL
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Ub4ix Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ub4ix2396736-46-0ProteasomeApoptosisDeubiquitinaseDUBsInhibitorinhibitorinhibit

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