2. Metabolic Enzyme/Protease Apoptosis Cell Cycle/DNA Damage
  3. Proteasome Apoptosis Deubiquitinase
  4. Ub4ix

Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM.

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Ub4ix Chemical Structure

Ub4ix Chemical Structure

CAS No. : 2396736-46-0

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Ub4ix Related Antibodies

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USP1 USP2 USP7 USP8 USP30 UCHL1

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Description

Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM[1][2].
Molecular Weight

1767.91

Formula

C84H106N18O23S
CAS No.
Sequence

cyclo(Ac-{d-Trp}-Leu-Tyr-Leu-Asp-Asp-Ser-Gly-Asp-Trp-Trp-Ile-Cys)-Gly-NH2, cyclized via thioether
Sequence Shortening

cyclo(Ac-{d-Trp}-LYLDDSGDWWIC)-G-NH2, cyclized via thioether
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ub4ix Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ub4ix2396736-46-0ProteasomeApoptosisDeubiquitinaseDUBsInhibitorinhibitorinhibit

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