UCB7362 

UCB7362 is an orally active and potent antimalarial plasmepsin X (PMX) inhibitor, with an IC₅₀ of 7 nM. UCB7362 inhibits parasite growth^[1].

UCB7362 is substantially more potent against PMX than PMIX with an IC₅₀ of 7 nM for the former compared to 142 nM for the latter^[1].
UCB7362 also demonstrates an improvement in selectivity against Cat D and Renin with an IC₅₀ of 3889 nM and >10,000 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UCB7362 (10-60 mg/kg, Oral administration, twice a day, for 4 days) clears parasitemia from peripheral blood^[1].
UCB7362 (IV (1 mg/kg), PO (10 mg/kg); once) shows moderate clearance in dog and cynomolgus monkey and moderate-high in rat^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

516.42

C₂₅H₂₇Cl₂N₅O₃

O=C(NC1=CC=CC([C@@](CC(N2[C@@H]3C[C@H](C)OCC3)=O)(C)NC2=N)=C1Cl)C4=CC=CC(C#N)=C4.[H]Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lowe MA, et al. Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362. J Med Chem. 2022 Oct 10.  [Content Brief]