2. Membrane Transporter/Ion Channel
  3. CFTR
  4. UCCF-853

UCCF-853 is a CFTR modulator.

For research use only. We do not sell to patients.

UCCF-853 Chemical Structure

UCCF-853 Chemical Structure

CAS No. : 625458-06-2

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5 mg USD 90 In-stock
10 mg USD 140 In-stock
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UCCF-853 Related Antibodies

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Description

UCCF-853 is a CFTR modulator[1].

Molecular Weight

312.67

Formula

C14H8ClF3N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC=C(C=C2N1)C(F)(F)F)C3=CC=CC(Cl)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (399.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1983 mL 15.9913 mL 31.9826 mL
5 mM 0.6397 mL 3.1983 mL 6.3965 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1983 mL 15.9913 mL 31.9826 mL 79.9565 mL
5 mM 0.6397 mL 3.1983 mL 6.3965 mL 15.9913 mL
10 mM 0.3198 mL 1.5991 mL 3.1983 mL 7.9957 mL
15 mM 0.2132 mL 1.0661 mL 2.1322 mL 5.3304 mL
20 mM 0.1599 mL 0.7996 mL 1.5991 mL 3.9978 mL
25 mM 0.1279 mL 0.6397 mL 1.2793 mL 3.1983 mL
30 mM 0.1066 mL 0.5330 mL 1.0661 mL 2.6652 mL
40 mM 0.0800 mL 0.3998 mL 0.7996 mL 1.9989 mL
50 mM 0.0640 mL 0.3198 mL 0.6397 mL 1.5991 mL
60 mM 0.0533 mL 0.2665 mL 0.5330 mL 1.3326 mL
80 mM 0.0400 mL 0.1999 mL 0.3998 mL 0.9995 mL
100 mM 0.0320 mL 0.1599 mL 0.3198 mL 0.7996 mL
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UCCF-853 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UCCF-853625458-06-2UCCF853UCCF 853CFTRCystic fibrosis transmembrane conductance regulatorInhibitorinhibitorinhibit

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