Umbelliferone-d₅ (Synonyms: 7-Hydroxycoumarin-d₅; Hydrangin-d₅; NSC 19790-d₅)

Cat. No.: HY-N0573S: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Umbelliferone-d₅ is the deuterium labeled Umbelliferone. Umbelliferone (7-Hydroxycoumarin), a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent.

For research use only. We do not sell to patients.

Umbelliferone-d<sub>5</sub> Chemical Structure

Umbelliferone-d₅ Chemical Structure

CAS No. : 1215373-23-1

Size	Price	Stock
2.5 mg	USD 950	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of Umbelliferone-d₅:

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Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

167.17

Formula

C₉HD₅O₃

CAS No.

1215373-23-1

Unlabeled CAS

93-35-6

Appearance

Solid

Color

White to off-white

SMILES

OC1=C([2H])C([2H])=C(C([2H])=C([2H])C(O2)=O)C2=C1[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 14.29 mg/mL (85.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 0.1 mg/mL (0.60 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.9819 mL	29.9097 mL	59.8193 mL
5 mM	1.1964 mL	5.9819 mL	11.9639 mL
10 mM	0.5982 mL	2.9910 mL	5.9819 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (252 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Yu SM, et al. Umbelliferone exhibits anticancer activity via the induction of apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells. Mol Med Rep. 2015 Sep;12(3):3869-3873. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	5.9819 mL	29.9097 mL	59.8193 mL	149.5484 mL
	5 mM	1.1964 mL	5.9819 mL	11.9639 mL	29.9097 mL
	10 mM	0.5982 mL	2.9910 mL	5.9819 mL	14.9548 mL
	15 mM	0.3988 mL	1.9940 mL	3.9880 mL	9.9699 mL
	20 mM	0.2991 mL	1.4955 mL	2.9910 mL	7.4774 mL
	25 mM	0.2393 mL	1.1964 mL	2.3928 mL	5.9819 mL
	30 mM	0.1994 mL	0.9970 mL	1.9940 mL	4.9849 mL
	40 mM	0.1495 mL	0.7477 mL	1.4955 mL	3.7387 mL
	50 mM	0.1196 mL	0.5982 mL	1.1964 mL	2.9910 mL
	60 mM	0.0997 mL	0.4985 mL	0.9970 mL	2.4925 mL
	80 mM	0.0748 mL	0.3739 mL	0.7477 mL	1.8694 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Umbelliferone-d₅ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Umbelliferone-d₅1215373-23-17-Hydroxycoumarin-d₅Hydrangin-d₅NSC 19790-d₅Endogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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Umbelliferone-d5 (Synonyms: 7-Hydroxycoumarin-d5; Hydrangin-d5; NSC 19790-d5)

Other Forms of Umbelliferone-d5:

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