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  4. Upadacitinib-15N,d2

Upadacitinib-15N,d2  (Synonyms: ABT-494-15N,d2)

Cat. No.: HY-W727879
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Upadacitinib-15N,d2 (ABT-494-15N,d2) is the deuterium-labeled Upadacitinib (HY-19569). Upadacitinib-15N,d2 (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib-15N,d2 (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib-15N,d2 (ABT-494) can be used for several autoimmune disorders research.

For research use only. We do not sell to patients.

Upadacitinib-<sup>15</sup>N,d<sub>2</sub> Chemical Structure

Upadacitinib-15N,d2 Chemical Structure

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1 mg USD 560 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Upadacitinib-15N,d2:

Upadacitinib-15N,d2 Related Antibodies

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Description

Upadacitinib-15N,d2 (ABT-494-15N,d2) is the deuterium-labeled Upadacitinib (HY-19569). Upadacitinib-15N,d2 (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib-15N,d2 (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib-15N,d2 (ABT-494) can be used for several autoimmune disorders research[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Upadacitinib-15N,d2 Related Antibodies
Molecular Weight

383.37

Formula

C17H17D2F3N515NO
Appearance

Solid

Color

White to off-white

SMILES

CC[C@H]1[C@H](CN(C1)C([15NH]C([2H])([2H])C(F)(F)F)=O)C2=CN=C3C=NC(NC=C4)=C4N23
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (260.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 100 mg/mL (260.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6084 mL 13.0422 mL 26.0845 mL
5 mM 0.5217 mL 2.6084 mL 5.2169 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.6084 mL 13.0422 mL 26.0845 mL 65.2112 mL
5 mM 0.5217 mL 2.6084 mL 5.2169 mL 13.0422 mL
10 mM 0.2608 mL 1.3042 mL 2.6084 mL 6.5211 mL
15 mM 0.1739 mL 0.8695 mL 1.7390 mL 4.3474 mL
20 mM 0.1304 mL 0.6521 mL 1.3042 mL 3.2606 mL
25 mM 0.1043 mL 0.5217 mL 1.0434 mL 2.6084 mL
30 mM 0.0869 mL 0.4347 mL 0.8695 mL 2.1737 mL
40 mM 0.0652 mL 0.3261 mL 0.6521 mL 1.6303 mL
50 mM 0.0522 mL 0.2608 mL 0.5217 mL 1.3042 mL
60 mM 0.0435 mL 0.2174 mL 0.4347 mL 1.0869 mL
80 mM 0.0326 mL 0.1630 mL 0.3261 mL 0.8151 mL
100 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.6521 mL
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Upadacitinib-15N,d2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Upadacitinib-15N,d2ABT-494-15N,d2Isotope-Labeled CompoundsJAK1orally activeautoimmuneInhibitorinhibitorinhibit

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