2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. Upadacitinib tartrate tetrahydrate

Upadacitinib tartrate tetrahydrate  (Synonyms: ABT-494 tartrate tetrahydrate)

Cat. No.: HY-19569A
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Upadacitinib (ABT-494) tartrate tetrahydrate is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib tartrate tetrahydrate displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib tartrate tetrahydrate can be used for several autoimmune disorders research.

For research use only. We do not sell to patients.

Upadacitinib tartrate tetrahydrate Chemical Structure

Upadacitinib tartrate tetrahydrate Chemical Structure

CAS No. : 1607431-21-9

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Upadacitinib tartrate tetrahydrate Related Antibodies

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Description

Upadacitinib (ABT-494) tartrate tetrahydrate is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib tartrate tetrahydrate displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib tartrate tetrahydrate can be used for several autoimmune disorders research[1][2].

IC50 & Target[1]

JAK1

0.043 μM (IC50)

JAK2

0.2 μM (IC50)

JAK3

2.3 μM (IC50)

Tyk2

4.7 μM (IC50)

In Vitro

In biochemical assays, Upadacitinib tartrate tetrahydrate is 74-fold more selective for JAK-1 than for JAK-2 (which is involved in erythropoiesis) and 58-fold more selective for JAK-1 than for JAK-3 (which is involved in immunosurveillance)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Upadacitinib tartrate tetrahydrate Related Antibodies
In Vivo

Upadacitinib (0.1-10 mg/kg; oral gavage; twice a day for 10 days) tartrate tetrahydrate demonstrates efficacy in rat arthritis models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Lewis rats (Rat adjuvant-induced arthritis model)[3]
Dosage: 0.1, 0.3, 1, 3, 10 mg/kg
Administration: Oral gavage; twice a day for 10 days
Result: Inhibited disease pathology in rat adjuvant induced arthritis.
Clinical Trial
Molecular Weight

602.52

Formula

C17H19F3N6O.C4H6O6.4H2O
CAS No.
SMILES

O=C(NCC(F)(F)F)N1C[C@H]([C@H](C1)C2=CN=C3C=NC4=C(N32)C=CN4)CC.O=C([C@@H]([C@H](C(O)=O)O)O)O.[4.H2O]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Upadacitinib tartrate tetrahydrate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Upadacitinib tartrate tetrahydrate1607431-21-9ABT-494 tartrate tetrahydrateJAKJanus kinaseInhibitorinhibitorinhibit

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