USP30 inhibitor 11

Name: USP30 inhibitor 11
Brand: MedChemExpress
SKU: HY-111623
Rating: 4.5 (1 reviews)

Cat. No.: HY-111623 Purity: 99.81%: FAQs
Data Sheet SDS COA Handling Instructions

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USP30 inhibitor 11 is a selective and potent ubiquitin specific peptidase 30 (USP30) inhibitor with an IC₅₀ of 0.01 µΜ, the example 83 extracted from patent WO2017009650A1. USP30 inhibitor 11 is used for the study of cancer and conditions involving mitochondrial dysfunction.

For research use only. We do not sell to patients.

USP30 inhibitor 11 Chemical Structure

CAS No. : 2067332-64-1

Size	Price	Stock	Quantity
1 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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USP1 USP2 USP7 USP8 USP30 UCHL1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 0.01 µΜ (USP30)^[1]

In Vitro

USP30 is a 517 amino acid protein which is found in the mitochondrial outer membrane. It is the sole deubiquitylating enzyme bearing a mitochondrial addressing signal and has been shown to deubiquitylate a number of mitochondrial proteins^[1].
USP30 inhibitor 11 (0.01-30 µΜ; λ_Ex=540 nm; λ_Em=590 nm) inhibits USP30 biochemical activity with an IC₅₀ of 0.01 µΜ in a USP30 biochemical IC₅₀ assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

368.41

Formula

C₁₇H₁₆N₆O₂S

CAS No.

2067332-64-1

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1N(C#N)CCC1)N(C2=NC(C3=NC(C#N)=C(OC)C=C3)=CS2)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL (90.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7144 mL	13.5718 mL	27.1437 mL
5 mM	0.5429 mL	2.7144 mL	5.4287 mL
10 mM	0.2714 mL	1.3572 mL	2.7144 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.81%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (251 KB) HNMR (140 KB) RP-HPLC (167 KB)

Handling Instructions (2659 KB)

References

[1]. Mark Kemp, et al. Cyanopyrrolidines as dub inhibitors for the treatment of cancer. Patent WO 2017009650 A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7144 mL	13.5718 mL	27.1437 mL	67.8592 mL
	5 mM	0.5429 mL	2.7144 mL	5.4287 mL	13.5718 mL
	10 mM	0.2714 mL	1.3572 mL	2.7144 mL	6.7859 mL
	15 mM	0.1810 mL	0.9048 mL	1.8096 mL	4.5239 mL
	20 mM	0.1357 mL	0.6786 mL	1.3572 mL	3.3930 mL
	25 mM	0.1086 mL	0.5429 mL	1.0857 mL	2.7144 mL
	30 mM	0.0905 mL	0.4524 mL	0.9048 mL	2.2620 mL
	40 mM	0.0679 mL	0.3393 mL	0.6786 mL	1.6965 mL
	50 mM	0.0543 mL	0.2714 mL	0.5429 mL	1.3572 mL
	60 mM	0.0452 mL	0.2262 mL	0.4524 mL	1.1310 mL
	80 mM	0.0339 mL	0.1696 mL	0.3393 mL	0.8482 mL