Valacyclovir-d₈ hydrochloride

Name: Valacyclovir-d 8 hydrochloride
Brand: MedChemExpress
SKU: HY-17425AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-17425AS Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Valacyclovir-d₈ (hydrochloride) is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) [1][2][3][4][5].

For research use only. We do not sell to patients.

Valacyclovir-d<sub>8</sub> hydrochloride Chemical Structure

Valacyclovir-d₈ hydrochloride Chemical Structure

CAS No. : 1279033-32-7

Size	Price	Stock	Quantity
1 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Valacyclovir-d₈ hydrochloride:

Valacyclovir hydrochloride In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

368.85

Formula

C₁₃H₁₃D₈ClN₆O₄

CAS No.

1279033-32-7

Unlabeled CAS

124832-27-5

Appearance

Solid

Color

White to off-white

SMILES

NC(C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])([2H])C(OCCOCN1C=NC2=C1N=C(N)NC2=O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

PBS (pH 7.2) : ≥ 10 mg/mL (27.11 mM)

DMF : ≥ 10 mg/mL (27.11 mM)

DMSO : ≥ 3 mg/mL (8.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7111 mL	13.5556 mL	27.1113 mL
5 mM	0.5422 mL	2.7111 mL	5.4223 mL
10 mM	0.2711 mL	1.3556 mL	2.7111 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (251 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Valacyclovir. New indication: for genital herpes, simpler administration. Can Fam Physician. 1999 Jul;45:1698-700, 1703-5. [Content Brief]

[3]. Lycke J, et al. Acyclovir levels in serum and cerebrospinal fluid after oral administration of valacyclovir. Antimicrob Agents Chemother. 2003 Aug;47(8):2438-41. [Content Brief]

[4]. Comparison of efficacies of famciclovir and valaciclovir against herpes simplex virus type 1 in a murineimmunosuppression model. Antimicrob Agents Chemother. 1995 May;39(5):1114-9. [Content Brief]

[5]. Dhaliwal DK, Romanowski EG, Yates KA, Valacyclovir inhibits recovery of ocular HSV-1 after experimental reactivation by excimer laser keratectomy. Cornea. 1999 Nov;18(6):693-9. [Content Brief]

[6]. Guo A, Hu P, Balimane PV, Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line.J Pharmacol Exp Ther. 1999 Apr;289(1):448-54. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO / PBS (pH 7.2) / DMF / DMF	1 mM	2.7111 mL	13.5556 mL	27.1113 mL	67.7782 mL
DMSO / DMSO / PBS (pH 7.2) / DMF / DMF	5 mM	0.5422 mL	2.7111 mL	5.4223 mL	13.5556 mL
PBS (pH 7.2) / DMF / DMF	10 mM	0.2711 mL	1.3556 mL	2.7111 mL	6.7778 mL
	15 mM	0.1807 mL	0.9037 mL	1.8074 mL	4.5185 mL
	20 mM	0.1356 mL	0.6778 mL	1.3556 mL	3.3889 mL
	25 mM	0.1084 mL	0.5422 mL	1.0845 mL	2.7111 mL