Valnemulin

Cat. No.: HY-113829: FAQs
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Valnemulin is an orally active broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria, anaerobic bacteria, Mycoplasma, and Spirochetes. Valnemulin ameliorates enteric diseases, acute polyarthritis and enzootic pneumonia in pigs. Valnemulin exhibits anti-inflammatory efficacy against lipopolysaccharide (HY-D1056)-induced lung injury.

For research use only. We do not sell to patients.

Valnemulin Chemical Structure

CAS No. : 101312-92-9

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Other In-stock Forms of Valnemulin:

Valnemulin hydrochloride

Other Forms of Valnemulin:

Valnemulin hydrochloride In-stock

2 Publications Citing Use of MCE Valnemulin

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Biological Activity
Purity & Documentation
References
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Description

Valnemulin is an orally active broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria, anaerobic bacteria, Mycoplasma, and Spirochetes. Valnemulin ameliorates enteric diseases, acute polyarthritis and enzootic pneumonia in pigs^[1]. Valnemulin exhibits anti-inflammatory efficacy against lipopolysaccharide (HY-D1056)-induced lung injury^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	IC₅₀	14.9 μg/mL Compound: Valnemulin	Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay	[PMID: 28291943]
Vero	IC₅₀	15 μg/mL Compound: Valnemulin	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30145051]

In Vitro

Valnemulin exhibits antimicrobial efficacy against Mycoplasma hyopneumoniae and Mycoplasma hyosynoviae, with MIC₉₀s of 0.0005 μg/mL and 0.0001 to 0.00025 μg/mL, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Valnemulin (100 mg/kg, i.g., single dose) exhibits lung protectiv effects in LPS-induced acute lung injury in BALB/c mice^[2].
Valnemulin hydrochloride (10 mg/kg, p.o.; 10 days) has a control effect in experimental infection of calves with Mycoplasma bovis, and can effectively eliminate Mycobacterium bovis in the lungs ^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Lipopolysaccharide induced acute lung injury in BALB/c mice^[2].
Dosage:	100 mg/kg
Administration:	i.g., single dose
Result:	Reduced levels of neutrophils, lymphocytes and macrophages, and expressions of TNF-α, IL-6, and IL-1β in bronchoalveolar lavage fluid (BALF). Increased superoxidase dismutase (SOD) activity in BALF, decreased myeloperoxidase (MAO) activity in lung.

Animal Model:	Mycoplasma bovis infection treated male calves aged 10-35 days^[3]
Dosage:	10 mg/kg
Administration:	p.o., 10 days
Result:	Resulted in a rapid diminution of clinical signs, restoration of appetite and reversal of weight loss. Effectively reduced the isolation of Pasteurella multocida from the calves^, lungs.

Molecular Weight

564.82

Formula

C₃₁H₅₂N₂O₅S

CAS No.

101312-92-9

SMILES

O=C(O[C@H]1[C@@]([C@H](C)CC2)(C)[C@@](C(CC3)=O)([H])[C@]32[C@@H](C)[C@H](O)[C@](C)(C=C)C1)CSC(C)(C)CNC([C@H](N)C(C)C)=O

Structure Classification

Others

Initial Source

Animals

pig

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hannan PC, et al., In vitro susceptibilities of recent field isolates of Mycoplasma hyopneumoniae and Mycoplasma hyosynoviae to valnemulin (Econor), tiamulin and enrofloxacin and the in vitro development of resistance to certain antimicrobial agents in Mycoplasma hyopneumoniae. Res Vet Sci. 1997 Sep-Oct;63(2):157-60. [Content Brief]

[2]. Chen Z, et al., Preventive effects of valnemulin on lipopolysaccharide-induced acute lung injury in mice. Inflammation. 2010 Oct;33(5):306-14. [Content Brief]

[3]. L. Stipkovits, et al. The efficacy of valnemulin (Econor®) in the control of disease caused by experimental infection of calves with Mycoplasma bovis. Research in Veterinary Science, Volume 78, Issue 3, June 2005, Pages 207–215.

Valnemulin Related Classifications

Inflammation/Immunology Infection

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valnemulin101312-92-9AntibioticBacterialMycoplasma hyopneumoniaeMycoplasma hyosynoviaeBALB/c miceacute lung injuryInhibitorinhibitorinhibit

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