1. Anti-infection
  2. Antibiotic Bacterial
  3. Valnemulin

Valnemulin is an orally active broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria, anaerobic bacteria, Mycoplasma, and Spirochetes. Valnemulin ameliorates enteric diseases, acute polyarthritis and enzootic pneumonia in pigs. Valnemulin exhibits anti-inflammatory efficacy against lipopolysaccharide (HY-D1056)-induced lung injury.

For research use only. We do not sell to patients.

Valnemulin Chemical Structure

Valnemulin Chemical Structure

CAS No. : 101312-92-9

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Description

Valnemulin is an orally active broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria, anaerobic bacteria, Mycoplasma, and Spirochetes. Valnemulin ameliorates enteric diseases, acute polyarthritis and enzootic pneumonia in pigs[1]. Valnemulin exhibits anti-inflammatory efficacy against lipopolysaccharide (HY-D1056)-induced lung injury[2].

Cellular Effect
Cell Line Type Value Description References
Vero IC50
14.9 μg/mL
Compound: Valnemulin
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
[PMID: 28291943]
Vero IC50
15 μg/mL
Compound: Valnemulin
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 30145051]
In Vitro

Valnemulin exhibits antimicrobial efficacy against Mycoplasma hyopneumoniae and Mycoplasma hyosynoviae, with MIC90s of 0.0005 μg/mL and 0.0001 to 0.00025 μg/mL, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Valnemulin (100 mg/kg, i.g., single dose) exhibits lung protectiv effects in LPS-induced acute lung injury in BALB/c mice[2].
Valnemulin hydrochloride (10 mg/kg, p.o.; 10 days) has a control effect in experimental infection of calves with Mycoplasma bovis, and can effectively eliminate Mycobacterium bovis in the lungs [3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lipopolysaccharide induced acute lung injury in BALB/c mice[2].
Dosage: 100 mg/kg
Administration: i.g., single dose
Result: Reduced levels of neutrophils, lymphocytes and macrophages, and expressions of TNF-α, IL-6, and IL-1β in bronchoalveolar lavage fluid (BALF).
Increased superoxidase dismutase (SOD) activity in BALF, decreased myeloperoxidase (MAO) activity in lung.
Animal Model: Mycoplasma bovis infection treated male calves aged 10-35 days[3]
Dosage: 10 mg/kg
Administration: p.o., 10 days
Result: Resulted in a rapid diminution of clinical signs, restoration of appetite and reversal of weight loss.
Effectively reduced the isolation of Pasteurella multocida from the calves, lungs.
Molecular Weight

564.82

Formula

C31H52N2O5S

CAS No.
SMILES

O=C(O[C@H]1[C@@]([C@H](C)CC2)(C)[C@@](C(CC3)=O)([H])[C@]32[C@@H](C)[C@H](O)[C@](C)(C=C)C1)CSC(C)(C)CNC([C@H](N)C(C)C)=O

Structure Classification
Initial Source

pig

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Valnemulin
Cat. No.:
HY-113829
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