Valnemulin hydrochloride

Name: Valnemulin hydrochloride
Brand: MedChemExpress
SKU: HY-B0027
Rating: 5.0 (2 reviews)

Cat. No.: HY-B0027 Purity: 98.03%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Valnemulin hydrochloride is an orally effective truncated pleurotin antibiotic that inhibits protein synthesis in bacteria by binding to peptidyl transferase in the 50s ribosome subunit. Valnemulin hydrochloride effectively eliminates Mycobacterium bovis in the lungs in an experimental bovine model of Mycoplasma bovis infection. Valnemulin hydrochloride can reduce the mortality of epidemic rabbit enteropathy and has no adverse effect on the growth performance of rabbits.

For research use only. We do not sell to patients.

Valnemulin hydrochloride Chemical Structure

CAS No. : 133868-46-9

Size	Stock	Quantity

Free Sample (0.1 - 0.5 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Valnemulin hydrochloride:

Valnemulin-d6 TFA Get quote
Valnemulin Get quote
Valnemulin (hydrochloride) (Standard) Get quote

2 Publications Citing Use of MCE Valnemulin hydrochloride

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

Valnemulin hydrochloride (10 mg/kg in non-salt form; Oral administration; 10 days) has a control effect in experimental infection of calves with Mycoplasma bovis, and can effectively eliminate Mycobacterium bovis in the lungs ^[1].
Valnemulin hydrochloride (20-35 ppm; Feed administration; 21 days) effectively reduces the mortality of epidemic rabbit enteropathy, and has no adverse effect on the growth performance of rabbits ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mycoplasma bovis infection treated male calves aged 10-35 days^[1]
Dosage:	10 mg/kg in non-salt form
Administration:	Oral administration (p.o.); 10 days
Result:	Resulted in a rapid diminution of clinical signs, restoration of appetite and reversal of weight loss. Effectively reduced the isolation of Pasteurella multocida from the calves^, lungs.

Animal Model:	Hycole strain rabbits aged 33-37 days with epizootic rabbit enteropathy^[2]
Dosage:	20 or 35 parts per million (ppm)
Administration:	Feed administration; 21 days
Result:	Reduced rabbit mortality. Epizootic rabbit enteropathy mortality was 23% in untreated rabbits and 11% and 7.6% in rabbits treated with 20 and 35 ppm doses, respectively. Had no detrimental effects on appetite, weight gain or feed conversion rate.

Molecular Weight

601.28

Formula

C₃₁H₅₃ClN₂O₅S

CAS No.

133868-46-9

Appearance

Solid

Color

White to off-white

SMILES

C[C@@H]([C@@H]([C@@](C)(C[C@H]1OC(CSC(C)(C)CNC([C@H](N)C(C)C)=O)=O)C=C)O)C(CCC2=O)(CC[C@H]3C)[C@]2([H])C31C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (166.31 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (166.31 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6631 mL	8.3156 mL	16.6312 mL
5 mM	0.3326 mL	1.6631 mL	3.3262 mL
10 mM	0.1663 mL	0.8316 mL	1.6631 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.16 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.16 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.16 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (166.31 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.03%

Select Batch:

Data Sheet (277 KB) SDS (537 KB)

COA (252 KB) RP-HPLC (245 KB)

Handling Instructions (2659 KB)

References

[1]. L. Stipkovits, et al. The efficacy of valnemulin (Econor®) in the control of disease caused by experimental infection of calves with Mycoplasma bovis. Research in Veterinary Science, Volume 78, Issue 3, June 2005, Pages 207–215.

[2]. Dip R, et al. Efficacy and tolerability of early administration of valnemulin hydrochloride premix on epizootic rabbit enteropathy. Vet J. 2015 Jun;204(3):309-14. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.6631 mL	8.3156 mL	16.6312 mL	41.5780 mL
	5 mM	0.3326 mL	1.6631 mL	3.3262 mL	8.3156 mL
	10 mM	0.1663 mL	0.8316 mL	1.6631 mL	4.1578 mL
	15 mM	0.1109 mL	0.5544 mL	1.1087 mL	2.7719 mL
	20 mM	0.0832 mL	0.4158 mL	0.8316 mL	2.0789 mL
	25 mM	0.0665 mL	0.3326 mL	0.6652 mL	1.6631 mL
	30 mM	0.0554 mL	0.2772 mL	0.5544 mL	1.3859 mL
	40 mM	0.0416 mL	0.2079 mL	0.4158 mL	1.0394 mL
	50 mM	0.0333 mL	0.1663 mL	0.3326 mL	0.8316 mL
	60 mM	0.0277 mL	0.1386 mL	0.2772 mL	0.6930 mL
	80 mM	0.0208 mL	0.1039 mL	0.2079 mL	0.5197 mL
	100 mM	0.0166 mL	0.0832 mL	0.1663 mL	0.4158 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.