Vanillylmandelic acid-d₃

Name: Vanillylmandelic acid-d 3
Brand: MedChemExpress
SKU: HY-113121S
Rating: 4.5 (1 reviews)

Cat. No.: HY-113121S Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Vanillylmandelic acid-d₃ is the deuterium labeled Vanillylmandelic acid. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM[1].

For research use only. We do not sell to patients.

Vanillylmandelic acid-d<sub>3</sub> Chemical Structure

Vanillylmandelic acid-d₃ Chemical Structure

CAS No. : 74495-70-8

Size	Price	Stock	Quantity
1 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 710	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Vanillylmandelic acid-d₃:

Vanillylmandelic acid Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

201.19

Formula

C₉H₇D₃O₅

CAS No.

74495-70-8

Unlabeled CAS

55-10-7

Appearance

Solid

Color

Light brown to brown

SMILES

OC(C(C1=CC(OC([2H])([2H])[2H])=C(C=C1)O)O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (621.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.9704 mL	24.8521 mL	49.7043 mL
5 mM	0.9941 mL	4.9704 mL	9.9409 mL
10 mM	0.4970 mL	2.4852 mL	4.9704 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (248 KB) HNMR (259 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Michalis K Kolentinis, et al.Cardiovascular effects of vanillylmandelic acid in rats. Eur J Pharmacol. 2013 Mar 5;703(1-3):46-52. [Content Brief]

[3]. Dušan Dimić, et al. Experimental and theoretical elucidation of structural and antioxidant properties of vanillylmandelic acid and its carboxylate anion. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jun 5;198:61-70. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.9704 mL	24.8521 mL	49.7043 mL	124.2606 mL
	5 mM	0.9941 mL	4.9704 mL	9.9409 mL	24.8521 mL
	10 mM	0.4970 mL	2.4852 mL	4.9704 mL	12.4261 mL
	15 mM	0.3314 mL	1.6568 mL	3.3136 mL	8.2840 mL
	20 mM	0.2485 mL	1.2426 mL	2.4852 mL	6.2130 mL
	25 mM	0.1988 mL	0.9941 mL	1.9882 mL	4.9704 mL
	30 mM	0.1657 mL	0.8284 mL	1.6568 mL	4.1420 mL
	40 mM	0.1243 mL	0.6213 mL	1.2426 mL	3.1065 mL
	50 mM	0.0994 mL	0.4970 mL	0.9941 mL	2.4852 mL
	60 mM	0.0828 mL	0.4142 mL	0.8284 mL	2.0710 mL
	80 mM	0.0621 mL	0.3107 mL	0.6213 mL	1.5533 mL
	100 mM	0.0497 mL	0.2485 mL	0.4970 mL	1.2426 mL