2. JAK/STAT Signaling
  3. Pim
  4. VB1080

VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5, 4996, 9.88 µM for PIM1, PIM2, PIM3, respectively. VB1080 shows cytotoxicity. VB1080 shows anthelmintic activity.

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VB1080 Chemical Structure

VB1080 Chemical Structure

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VB1080 Related Antibodies

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Description

VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5, 4996, 9.88 µM for PIM1, PIM2, PIM3, respectively. VB1080 shows cytotoxicity. VB1080 shows anthelmintic activity[1].

IC50 & Targetsup>[1]

PIM1

69.5 μM (IC50)

PIM2

4996 μM (IC50)

PIM3

9.88 μM (IC50)

Molecular Weight

441.52

Formula

C27H27N3O3
SMILES

CN(CCC1)CCN1C(C2=CC(C3=CC=C(O3)/C=C4C(NC5=C/4C=CC=C5C)=O)=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VB1080 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VB1080VB 1080VB-1080PimPim kinasesHepG2 cellsT. muris whipwormsA. ceylanicumanthelminticcytotoxicityInhibitorinhibitorinhibit

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