VEGFR-2/DHFR-IN-2

Cat. No.: HY-151459: FAQs
Data Sheet Handling Instructions

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VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC₅₀s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC₅₀ values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer.

For research use only. We do not sell to patients.

VEGFR-2/DHFR-IN-2 Chemical Structure

CAS No. : 2831498-09-8

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

VEGFR2

0.623 μM (IC₅₀)

DHFR

9.085 μM (IC₅₀)

In Vitro

VEGFR-2/DHFR-IN-2 (2-1024 μg/mL; 18-72 h) shows antibacterial and antifungal activities with MIC values of 64, 64, 32, 32, 16, 32, 64 and 256 μg/mL for Escherichia coli, Pseudomonas aeruginosa, Streptococcus faecalis, Salmonella enterica, MSSA, MRSA, Candida albicans and Aspergillus niger, respectively^[1].
VEGFR-2/DHFR-IN-2 (0.5-100 μM; 48 h) exhibits anticancer activities^[1].
VEGFR-2/DHFR-IN-2 (0-100 μM; 30 min) shows DHFR and VEGFR-2 inhibitory activities with IC₅₀s of 9.085 and 0.623 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	C26, HepG2, MCF7 and H69PR cell lines
Concentration:	0.5, 1, 5, 10, 25, 50, 80 and 100 μM
Incubation Time:	48 hours
Result:	Showed anticancer activities to C26, HepG2, MCF7 and H69PR cells with IC₅₀s of 3.59, 8.38, 6.75 and 28.45 μM, respectively.

Molecular Weight

351.40

Formula

C₂₁H₂₁NO₄

CAS No.

2831498-09-8

SMILES

O=C(NCC1=CC=C(C)C=C1)C2=CC(O)=C3C(OC)=CC(OC)=CC3=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pham EC, et al. Design, Microwave-Assisted Synthesis, Antimicrobial and Anticancer Evaluation, and In Silico Studies of Some 2-Naphthamide Derivatives as DHFR and VEGFR-2 Inhibitors. ACS. 2022.

VEGFR-2/DHFR-IN-2 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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